Two-component systems (TCS) comprising sensor histidine kinases and response regulator
proteins are among the most important players in bacterial and archaeal signal transduction …

Genomic studies have revealed the presence of Ser/Thr kinases and phosphatases in many
bacterial species, although their physiological roles have largely been unclear. Here we …

Group B streptococcus (GBS) is a β-hemolytic gram-positive bacterium that colonizes the
lower genital tract of approximately 18% of women globally as an asymptomatic member of …

Bacterial infections remain a significant threat to the health of newborns and adults. Group B
Streptococci (GBS) are Gram-positive bacteria that are common asymptomatic colonizers of …

Microbial infection of the amniotic fluid is a significant cause of fetal injury, preterm birth, and
newborn infections. Group B Streptococcus (GBS) is an important human bacterial pathogen …

Highlights•Ser/Thr phosphorylation is involved in the regulation of cell wall synthesis and
translation.•Ser/Thr kinases phosphorylate elements of two-component systems.•Ser/Thr …

Streptococcus agalactiae (Group B streptococcus, GBS) is highly adapted to humans, where
it is a normal constituent of the intestinal and vaginal flora. Yet, GBS has highly invasive …

Exotoxins, including the hemolysins known as the alpha (α) and beta (β) toxins, play an
important role in the pathogenesis of Staphylococcus aureus infections. A random …

Natural DNA transformation is a lateral gene transfer mechanism during which bacteria take
up naked DNA from their environment and stably integrate it in their genome. The proteins …

Bacterial two-component systems (TCSs) are signaling modules that control physiology,
adaptation, and host interactions. A typical TCS consists of a histidine kinase (HK) that …