The transcription factor SOX2 is essential for embryonic development and plays a crucial
role in maintaining the stemness of embryonic cells and various adult stem cell populations …

Cellular plasticity can occur naturally in an organism and is considered an adapting
mechanism during the developmental stage. However, abnormal cellular plasticity is …

Background In this study, we aimed to investigate the expression and clinical significance of
miR-145-5p and its tumor-suppressive effect in breast cancer patients. Methods We used …

Epithelial-mesenchymal transition (EMT) and ferroptosis are two important processes in
biology. In tumor cells, they are intimately linked. We used single-cell RNA sequencing to …

Abstract SRY (Sex Determining Region) box 2 (SOX2) is an essential transcription factor that
plays crucial roles in activating genes involved in pre-and post-embryonic development …

The gene of transcriptional repressor GATA binding 1 (TRPS1), as an atypical GATA
transcription factor, has received considerable attention in a plethora of physiological and …

Sox family of transcriptional factors play essential functions in development and are
implicated in multiple clinical disorders, including cancer. Sox2 being their most prominent …

The SOX genes encode a family of more than 20 transcription factors that are critical
regulators of embryogenesis and developmental processes and, when aberrantly …

Cancer stem cells (CSCs) are responsible for cancer recurrence, treatment failure and
metastatic dissemination. As such, the elimination of CSCs represents one of the most …

Synovial sarcoma is an aggressive translocation-associated soft tissue tumor driven by an
SS18-SSX fusion oncoprotein. TRPS1 is a recently identified marker for breast carcinoma …