Cell types are the basic functional units of an organism. Cell types exhibit diverse
phenotypic properties at multiple levels, making them challenging to define, categorize, and …

Cell type-specific gene expression patterns and dynamics during development or in disease
are controlled by cis-regulatory elements (CREs), such as promoters and enhancers …

The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally
conserved across mammals. Here, using high-throughput transcriptomic and epigenomic …

Here we report the generation of a multimodal cell census and atlas of the mammalian
primary motor cortex as the initial product of the BRAIN Initiative Cell Census Network …

The diversity and complex organization of cells in the brain have hindered systematic
characterization of age-related changes in its cellular and molecular architecture, limiting …

In mammalian brains, millions to billions of cells form complex interaction networks to enable
a wide range of functions. The enormous diversity and intricate organization of cells have …

The DNA methylation field has matured from a phase of discovery and genomic
characterization to one seeking deeper functional understanding of how this modification …

As inflammation in the brain contributes to several neurological and psychiatric diseases,
the cause of neuroinflammation is being widely studied. The causes of neuroinflammation …

Delineating the gene-regulatory programs underlying complex cell types is fundamental for
understanding brain function in health and disease. Here, we comprehensively examined …

Single-cell sequencing technologies, including transcriptomic and epigenomic assays, are
transforming our understanding of the cellular building blocks of neural circuits. By directly …