Protein lipidation: occurrence, mechanisms, biological functions, and enabling technologies
Protein lipidation, including cysteine prenylation, N-terminal glycine myristoylation, cysteine
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …
A not-so-ancient grease history: click chemistry and protein lipid modifications
Protein lipid modification involves the attachment of hydrophobic groups to proteins via
ester, thioester, amide, or thioether linkages. In this review, the specific click chemical …
ester, thioester, amide, or thioether linkages. In this review, the specific click chemical …
Myristoylation, an ancient protein modification mirroring eukaryogenesis and evolution
N-myristoylation (MYR) is a crucial fatty acylation catalyzed by N-myristoyltransferases
(NMTs) that is likely to have appeared over 2 billion years ago. Proteome-wide approaches …
(NMTs) that is likely to have appeared over 2 billion years ago. Proteome-wide approaches …
The current drug discovery landscape for trypanosomiasis and leishmaniasis: Challenges and strategies to identify drug targets
F Altamura, R Rajesh, CMC Catta‐Preta… - Drug development …, 2022 - Wiley Online Library
Human trypanosomiasis and leishmaniasis are vector‐borne neglected tropical diseases
caused by infection with the protozoan parasites Trypanosoma spp. and Leishmania spp …
caused by infection with the protozoan parasites Trypanosoma spp. and Leishmania spp …
Dual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics
EM Storck, J Morales-Sanfrutos, RA Serwa… - Nature Chemistry, 2019 - nature.com
Post-translational farnesylation or geranylgeranylation at a C-terminal cysteine residue
regulates the localization and function of over 100 proteins, including the Ras isoforms, and …
regulates the localization and function of over 100 proteins, including the Ras isoforms, and …
Dynamic protein acylation: new substrates, mechanisms, and drug targets
Post-translational attachment of lipids to proteins is found in all organisms, and is important
for many biological processes. Acylation with myristic and palmitic acids are among the most …
for many biological processes. Acylation with myristic and palmitic acids are among the most …
Protein palmitoylation and its role in bacterial and viral infections
J Sobocińska, P Roszczenko-Jasińska… - Frontiers in …, 2018 - frontiersin.org
S-palmitoylation is a reversible, enzymatic posttranslational modification of proteins in which
palmitoyl chain is attached to a cysteine residue via a thioester linkage. S-palmitoylation …
palmitoyl chain is attached to a cysteine residue via a thioester linkage. S-palmitoylation …
Proteome-wide analysis of protein lipidation using chemical probes: in-gel fluorescence visualization, identification and quantification of N-myristoylation, N- and S-acylation, O …
Protein lipidation is one of the most widespread post-translational modifications (PTMs)
found in nature, regulating protein function, structure and subcellular localization. Lipid …
found in nature, regulating protein function, structure and subcellular localization. Lipid …
Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani
V Corpas-Lopez, S Moniz, M Thomas… - ACS infectious …, 2018 - ACS Publications
Visceral leishmaniasis (VL), caused by the protozoan parasites Leishmania donovani and L.
infantum, is responsible for∼ 30 000 deaths annually. Available treatments are inadequate …
infantum, is responsible for∼ 30 000 deaths annually. Available treatments are inadequate …
Exploring N-myristoyltransferase as a promising drug target against parasitic neglected tropical diseases
Neglected tropical diseases (NTDs) constitute a group of approximately 20 infectious
diseases that mainly affect the impoverished population without basic sanitation in tropical …
diseases that mainly affect the impoverished population without basic sanitation in tropical …