Diabetes Mellitus (DM) is a multi-factorial chronic health condition that affects a large part of
population and according to the World Health Organization (WHO) the number of adults …

Although many kinds of therapies are applied in the clinic, drug-resistance is a major and
unavoidable problem. Another disturbing statistic is the limited number of drug targets, which …

Overcoming CD8+ T cell exhaustion is critical in cancer immunotherapy. Recently, an
intratumor stem/progenitor-like CD8+ T cell (Tprog cell) population that mediates the …

Regulatory B (Breg) cells are immunosuppressive cells that support immunological
tolerance. Through the production of interleukin-10 (IL-10), IL-35, and transforming growth …

Diffuse large B-cell lymphoma (DLBCL), the most frequent subtype of lymphoid malignancy,
remains a significant clinical challenge, as∼ 30% of patients are not cured. Over the past …

Germinal centres (GCs) are involved in the selection of B cells secreting high-affinity
antibodies and are also the origin of most human B cell lymphomas. Recent progress has …

The immune system can remember a previously experienced pathogen and can evoke an
enhanced response to reinfection that depends on memory lymphocyte populations. Recent …

Protease-targeted chimeras (PROTACs) are a new technology that is receiving much
attention in the treatment of diseases. The mechanism is to inhibit protein function by …

Germinal centers (GCs) were described more than 125 years ago as compartments within
secondary lymphoid organs that contained mitotic cells. Since then, it has become clear that …

Abstract DEAD-box helicase 17 (DDX17) is a typical member of the DEAD-box family with
transcriptional cofactor activity. Although DDX17 is abundantly expressed in the …