The role of CD95 and CD95 ligand in cancer
Abstract CD95 (Fas/APO-1) and its ligand, CD95L, have long been viewed as a death
receptor/death ligand system that mediates apoptosis induction to maintain immune …
receptor/death ligand system that mediates apoptosis induction to maintain immune …
The multifaceted role of TRAIL signaling in cancer and immunity
L Cardoso Alves, N Corazza, O Micheau… - The FEBS …, 2021 - Wiley Online Library
Tumor necrosis factor (TNF)‐related apoptosis‐inducing ligand (TRAIL) is a member of the
TNF superfamily that can lead to the induction of apoptosis in tumor or infected cells …
TNF superfamily that can lead to the induction of apoptosis in tumor or infected cells …
LY2109761, a novel transforming growth factor β receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis
D Melisi, S Ishiyama, GM Sclabas, JB Fleming… - Molecular cancer …, 2008 - AACR
Most pancreatic cancer patients present with inoperable disease or develop metastases
after surgery. Conventional therapies are usually ineffective in treating metastatic disease. It …
after surgery. Conventional therapies are usually ineffective in treating metastatic disease. It …
Anti–tumor necrosis factor therapy inhibits pancreatic tumor growth and metastasis
JH Egberts, V Cloosters, A Noack, B Schniewind… - Cancer research, 2008 - AACR
Chronic inflammation has been implicated in the pathogenesis of many severe autoimmune
disorders, as well as in diabetes, pulmonary diseases, and cancer. Inflammation …
disorders, as well as in diabetes, pulmonary diseases, and cancer. Inflammation …
Pancreatic cancer: basic and clinical aspects
More than 30,000 people develop pancreatic adeno-carcinoma each year in the United
States, and almost all are expected to die from the disease. 1 The 5-year survival rate is 5 …
States, and almost all are expected to die from the disease. 1 The 5-year survival rate is 5 …
Genetic alterations of TRAF proteins in human cancers
S Zhu, J **, S Gokhale, AM Lu, H Shan… - Frontiers in …, 2018 - frontiersin.org
The tumor necrosis factor receptor (TNF-R)-associated factor (TRAF) family of cytoplasmic
adaptor proteins regulate the signal transduction pathways of a variety of receptors …
adaptor proteins regulate the signal transduction pathways of a variety of receptors …
Liquidambaric acid inhibits Wnt/β-catenin signaling and colon cancer via targeting TNF receptor-associated factor 2
R Yan, H Zhu, P Huang, M Yang, M Shen, Y Pan… - Cell Reports, 2022 - cell.com
Wnt/β-catenin signaling is a well-established driver of colon cancer; however, a targeted
therapeutic agent has not reached clinics yet. In the present study, we report that the natural …
therapeutic agent has not reached clinics yet. In the present study, we report that the natural …
TRAIL promotes metastasis of human pancreatic ductal adenocarcinoma
A Trauzold, D Siegmund, B Schniewind, B Sipos… - Oncogene, 2006 - nature.com
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has attracted considerable
attention for its potential use in tumor therapy, as some recombinant variants of this ligand …
attention for its potential use in tumor therapy, as some recombinant variants of this ligand …
TRAF6 is an amplified oncogene bridging the RAS and NF-κB pathways in human lung cancer
Somatic mutations and copy number alterations (as a result of deletion or amplification of
large portions of a chromosome) are major drivers of human lung cancers. Detailed analysis …
large portions of a chromosome) are major drivers of human lung cancers. Detailed analysis …
NF-κB in pancreatic cancer: Its key role in chemoresistance
Q Li, G Yang, M Feng, S Zheng, Z Cao, J Qiu, L You… - Cancer letters, 2018 - Elsevier
Pancreatic cancer is considered a lethal disease with a high mortality and an extremely low
five-year survival rate. Chemotherapy plays a pivotal role in pancreatic cancer treatment …
five-year survival rate. Chemotherapy plays a pivotal role in pancreatic cancer treatment …