Currently, more than 170 modifications have been identified on RNA. Among these RNA
modifications, various methylations account for two-thirds of total cases and exist on almost …

In recent years, major breakthroughs in RNA-modification-mediated regulation of gene
expression have been made, leading to the emerging field of epitranscriptomics. Our …

Altered synaptic structure and function is a major hallmark of fragile X syndrome (FXS),
autism spectrum disorders (ASDs), and other intellectual disabilities (IDs), which are …

Small nucleolar RNAs (snoRNAs) are short non-protein-coding RNAs with a long-
recognized role in tuning ribosomal and spliceosomal function by guiding ribose methylation …

The ribose of RNA nucleotides can be 2′-O-methylated (Nm). Despite advances in high-
throughput detection, the inert chemical nature of Nm still limits sensitivity and precludes …

Fragile X syndrome (FXS) is the most frequent form of inherited intellectual disability and is
also linked to other neurologic and psychiatric disorders. FXS is caused by a triplet …

Nm (2′-O-methylation) is one of the most common modifications in the RNA world. It has
the potential to influence the RNA molecules in multiple ways, such as structure, stability …

Fragile X is the most common known inherited cause of intellectual disability and autism,
and it typically results from transcriptional silencing of FMR1 and loss of the encoded …

DNA and RNA contain, next to the four canonical nucleobases, a number of modified
nucleosides that extend their chemical information content. RNA is particularly rich in …

Analogous to DNA methylation and histone modifications, RNA modifications represent a
novel layer of regulation of gene expression. The dynamic nature and increasing number of …