Toxoplasma gondii causes fatal and debilitating brain and eye diseases. Medicines that are
currently used to treat toxoplasmosis commonly have toxic side effects and require …

The quinoline scaffold is prevalent in a variety of pharmacologically active synthetic and
natural compounds. The discovery of chloroquine, the most famous drug containing this …

THE METHODS OF SYNTHESIS, MODIFICATION, AND BIOLOGICAL ACTIVITY OF 4-QUINOLONES
(REVIEW) Page 1 Chemistry of Heterocyclic Compounds, Vol. 45, No. 7, 2009 THE …

The term “conformational restriction” can be found very often in contemporary chemical
literature. Despite the lack of strict definitions, this term is usually intuitively understood and …

Malaria, a parasite vector-borne disease, is one of the most significant health threats in
tropical regions, despite the availability of individual chemoprophylaxis. Malaria …

This paper reports on the rational design of a series of new 6-fluoroquinolones by QSAR
analysis against Toxoplasma (T.) gondii, their synthesis, their biological evaluation against …

Abstract A series of 5-substituted-1, 3, 4-thiadiazole-based fluoroquinolone derivatives were
designed as potential antibacterial and anticancer agents using a molecular hybridization …

Coccidiosis is a crucial parasitic disease of the poultry industry. As a result of the enormous
global economic losses and the increased resistance to the conventional anticoccidial …

Purpose Acanthamoeba is an opportunistic pathogen which is the causal agent of a sight-
threatening ulceration of the cornea known as “Acanthamoeba keratitis”(AK) and, more …

A series of phenylsubstituted pyrazolo and pyrimido benzothiazine dioxide derivatives were
synthesized and investigated for their abilities to inhibit β-hematin formation, hemoglobin …