Ethnopharmacological relevance Cannabis sativa L.(C. sativa) is an annual dioecious plant,
which shares its origins with the inception of the first agricultural human societies in Asia …

The use of the intoxicating cannabinoid delta‐8‐tetrahydrocannabinol (Δ8‐THC) has grown
rapidly over the last several years. There have been dozens of Δ8‐THC studies dating back …

Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …

Background Current arthritis treatments often have side‐effects attributable to active
compounds as well as route of administration. Cannabidiol (CBD) attenuates inflammation …

The amygdala plays key roles in fear and anxiety. Studies of the amygdala have largely
focused on neuronal function and connectivity. Astrocytes functionally interact with neurons …

The identification and cloning of the two major cannabinoid (CB1 and CB2) receptors
together with the discovery of their endogenous ligands in the late 80s and early 90s …

The psychoactive constituent in cannabis, Δ9-tetrahydrocannabinol (THC), was isolated in
the mid-1960s, but the cannabinoid receptors, CB1 and CB2, and the major endogenous …

Accumulating evidence indicates that astrocytes are actively involved in brain function by
regulating synaptic activity and plasticity. Different gliotransmitters, such as glutamate, ATP …

The balance between detrimental, pro-aging, often stochastic processes and counteracting
homeostatic mechanisms largely determines the progression of aging. There is substantial …

Hypothalamic pro-opiomelanocortin (POMC) neurons promote satiety. Cannabinoid
receptor 1 (CB1R) is critical for the central regulation of food intake. Here we test whether …