Opportunities and challenges for combining chemo-and biocatalysis

F Rudroff, MD Mihovilovic, H Gröger, R Snajdrova… - Nature Catalysis, 2018 - nature.com
The past decade has seen a substantial increase in successful examples of the combination
of chemo-and biocatalysis for multistep syntheses. This is driven by obvious advantages …

Biocatalytic oxidation reactions: a chemist's perspective

JJ Dong, E Fernández‐Fueyo… - Angewandte Chemie …, 2018 - Wiley Online Library
Oxidation chemistry using enzymes is approaching maturity and practical applicability in
organic synthesis. Oxidoreductases (enzymes catalysing redox reactions) enable chemists …

Artificial biocatalytic linear cascades for preparation of organic molecules

JH Schrittwieser, S Velikogne, M Hall… - Chemical reviews, 2018 - ACS Publications
The review compiles artificial cascades involving enzymes with a focus on the last 10 years.
A cascade is defined as the combination of at least two reaction steps in a single reaction …

Continuous‐flow technology—a tool for the safe manufacturing of active pharmaceutical ingredients

B Gutmann, D Cantillo… - Angewandte Chemie …, 2015 - Wiley Online Library
In the past few years, continuous‐flow reactors with channel dimensions in the micro‐or
millimeter region have found widespread application in organic synthesis. The characteristic …

Multienzyme Cascade Reactions Status and Recent Advances

JM Sperl, V Sieber - Acs Catalysis, 2018 - ACS Publications
Cascade reactions catalyzed by multienzymatic systems have strongly moved into the focus
of researchers in the field of biocatalysis because of their unique potential for the …

One-pot chemo-and photo-enzymatic linear cascade processes

JM Carceller, KS Arias, MJ Climent, S Iborra… - Chemical Society …, 2024 - pubs.rsc.org
The combination of chemo-and photocatalyses with biocatalysis, which couples the flexible
reactivity of the photo-and chemocatalysts with the highly selective and environmentally …

Cascade catalysis–strategies and challenges en route to preparative synthetic biology

J Muschiol, C Peters, N Oberleitner… - Chemical …, 2015 - pubs.rsc.org
Nature's smartness and efficient assembling cascade type reactions inspired biologists and
chemists all around the world. Tremendous effort has been directed towards the …

Construction of chemoenzymatic cascade reactions for bridging chemocatalysis and Biocatalysis: Principles, strategies and prospective

Y Liu, P Liu, S Gao, Z Wang, P Luan… - Chemical Engineering …, 2021 - Elsevier
Multi-step one-pot chemoenzymatic cascade reactions (mo-CECRs) bridging chemo-and
bio-catalysis can not only accomplish chemical transformations with minimized purification …

Flow fine synthesis with heterogeneous catalysts

K Masuda, T Ichitsuka, N Koumura, K Sato… - Tetrahedron, 2018 - Elsevier
In the past few decades, organic reactions under flow conditions have attracted increasing
attention. Flow reactions have a number of advantages over batch reactions in terms of …

Combining the 'two worlds' of chemocatalysis and biocatalysis towards multi-step one-pot processes in aqueous media

H Gröger, W Hummel - Current opinion in chemical biology, 2014 - Elsevier
Highlights•Combining the “two worlds” biocatalysis and chemocatalysis towards one-pot
syntheses in aqueous media is a promising concept for the development of both …