The classical studies of nicotine by Langley at the turn of the 20th century introduced the
concept of a “receptive substance,” from which the idea of a “receptor” came to light …

Substantial progress in the identification of genes encoding for a large number of proteins
responsible for various aspects of neurotransmitter release, postsynaptic detection and …

Neuronal nicotinic receptors (NAChRs) form a heterogeneous family of ion channels that are
differently expressed in many regions of the central nervous system (CNS) and peripheral …

Broad-scale in vitro pharmacology profiling of new chemical entities during early phases of
drug discovery has recently become an essential tool to predict clinical adverse effects …

In the develo** nervous system, patterned spontaneous activity affects a variety of
developmental processes. Thus, it is important to identify the earliest time that such activity …

Neuronal nicotinic acetylcholine receptors (nAChRs) have been a target for drug discovery
efforts, primarily for CNS indications, for the past two decades. While nicotine and related …

Neuronal nicotinic receptors (nAChRs) are a heterogeneous family of ion channels
differently expressed in the nervous system where, by responding to the endogenous …

A number of studies over the last two decades have demonstrated the critical importance of
dopamine (DA) in the behavioral pharmacology and addictive properties of abused drugs …

The present review summarizes the current knowledge of the cholinergic systems in the
airways with special emphasis on the role of acetylcholine both as neurotransmitter in …

Gymnodimines (GYMs) are phycotoxins exhibiting unusual structural features including a
spirocyclic imine ring system and a trisubstituted tetrahydrofuran embedded within a 16 …