Abstract Pyruvate kinase M2 (PKM2) is a key rate-limiting enzyme in glycolysis. It is well
known that PKM2 plays a vital role in the proliferation of tumor cells. However, PKM2 can …

Glycolysis is the fundamental cellular process that permits cancer cells to convert energy
and grow anaerobically. Recent developments in molecular biology have made it evident …

Objectives Oxidative stress, mitochondrial dysfunction, and apoptosis play significant roles
in the degradation of extracellular matrix (ECM) in nucleus pulposus cells (NPCs), ultimately …

Macrophages are highly heterogeneous and plastic immune cells that play an important role
in the fight against pathogenic microorganisms and tumor cells. After different stimuli …

Pyruvate Kinase M2, a key enzyme in glycolysis, has garnered significant attention in cancer
research due to its pivotal role in the metabolic reprogramming of cancer cells. Originally …

Pyruvate kinase M2 (PKM2), a crucial enzyme in the glycolysis pathway, is commonly
documented as being overexpressed in cancer cells. Inhibiting PKM2, a strategy to mitigate …

Pyruvate kinase M (PKM) 2 was described to interact with the inositol 1, 4, 5-trisphosphate
(IP3) receptor (IP3R) and suppress its activity. To further investigate the physiological …

Abstract The Nobel Prize Winner (1931) Dr. Otto H. Warburg had established that the
primary energy source of the cancer cell is aerobic glycolysis (the Warburg effect). He also …

Simple Summary Although many therapies have been applied in oral squamous cell
carcinoma, these therapies are still unsatisfactory. Recently, the mitochondrial role in oral …

Cancer metabolic reprogramming is a complex process that provides malignant cells with
selective advantages to grow and propagate in the hostile environment created by the …