In response to infection, naïve CD8+ T (TN) cells yield a large pool of short-lived terminal
effector (TTE) cells that eliminate infected host cells. In parallel, a minor population of stem …

Here we present the generation and characterization of patient-derived organoids (PDOs)
from colorectal cancer patients. PDOs derived from two patients with TP53 mutations were …

Nucleosomes are non-uniformly distributed across eukaryotic genomes, with stretches of
'open'chromatin strongly associated with transcriptionally active promoters and enhancers …

Gene expression is regulated by chromatin DNA methylation and other features, including
histone post-translational modifications (PTMs), chromatin remodelers and transcription …

In mammalian cells, SET8 mediated Histone H4 Lys 20 monomethylation (H4K20me1) has
been implicated in regulating mitotic condensation, DNA replication, DNA damage …

Accessible chromatin plays a central role in gene expression and chromatin architecture.
Current accessible chromatin approaches depend on limited digestion/cutting and pasting …

Background Accessible chromatin landscape allows binding of transcription factors, and
remodeling of promoter and enhancer elements during development. Chromatin …

Modification of histones provides a dynamic mechanism to regulate chromatin structure and
access to DNA. Histone acetylation, in particular, plays a prominent role in controlling the …

A genome-wide chromatin profiling technology, named as Nicking Enzyme Epitope targeted
DNA sequencing (NEED-seq) in which antibody-targeted controlled nicking by Nt. CviPII …

Nucleosomes are non-uniformly distributed across eukarytic genomes, with stretches of
'open'chromatin strongly associated with transcriptionally active promoters and enhancers …