Biological and functional multimorbidity—from mechanisms to management
Globally, the number of people with multiple co-occurring diseases will increase
substantially over the coming decades, with important consequences for patients, carers …
substantially over the coming decades, with important consequences for patients, carers …
Opportunities and obstacles for deep learning in biology and medicine
T Ching, DS Himmelstein… - Journal of the …, 2018 - royalsocietypublishing.org
Deep learning describes a class of machine learning algorithms that are capable of
combining raw inputs into layers of intermediate features. These algorithms have recently …
combining raw inputs into layers of intermediate features. These algorithms have recently …
[HTML][HTML] A deep learning algorithm to predict risk of pancreatic cancer from disease trajectories
Pancreatic cancer is an aggressive disease that typically presents late with poor outcomes,
indicating a pronounced need for early detection. In this study, we applied artificial …
indicating a pronounced need for early detection. In this study, we applied artificial …
Process mining for healthcare: Characteristics and challenges
Process mining techniques can be used to analyse business processes using the data
logged during their execution. These techniques are leveraged in a wide range of domains …
logged during their execution. These techniques are leveraged in a wide range of domains …
Association between socioeconomic status and the development of mental and physical health conditions in adulthood: a multi-cohort study
Background Socioeconomic disadvantage is a risk factor for many diseases. We
characterised cascades of these conditions by using a data-driven approach to examine the …
characterised cascades of these conditions by using a data-driven approach to examine the …
GRU-ODE-Bayes: Continuous modeling of sporadically-observed time series
Modeling real-world multidimensional time series can be particularly challenging when
these are sporadically observed (ie, sampling is irregular both in time and across …
these are sporadically observed (ie, sampling is irregular both in time and across …
Identifying and visualising multimorbidity and comorbidity patterns in patients in the English National Health Service: a population-based study
Background Globally, there is a paucity of multimorbidity and comorbidity data, especially for
minority ethnic groups and younger people. We estimated the frequency of common disease …
minority ethnic groups and younger people. We estimated the frequency of common disease …
[HTML][HTML] Predicting healthcare trajectories from medical records: A deep learning approach
Personalized predictive medicine necessitates the modeling of patient illness and care
processes, which inherently have long-term temporal dependencies. Healthcare …
processes, which inherently have long-term temporal dependencies. Healthcare …
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci
We simultaneously investigated the genetic landscape of ankylosing spondylitis, Crohn's
disease, psoriasis, primary sclerosing cholangitis and ulcerative colitis to investigate …
disease, psoriasis, primary sclerosing cholangitis and ulcerative colitis to investigate …
: A Convolutional Net for Medical Records
Feature engineering remains a major bottleneck when creating predictive systems from
electronic medical records. At present, an important missing element is detecting predictive …
electronic medical records. At present, an important missing element is detecting predictive …