Amyotrophic lateral sclerosis pathoetiology and pathophysiology: roles of astrocytes, gut microbiome, and muscle interactions via the mitochondrial melatonergic …
G Anderson - International Journal of Molecular Sciences, 2022 - mdpi.com
The pathoetiology and pathophysiology of motor neuron loss in amyotrophic lateral sclerosis
(ALS) are still to be determined, with only a small percentage of ALS patients having a …
(ALS) are still to be determined, with only a small percentage of ALS patients having a …
Common mechanisms underlying axonal transport deficits in neurodegenerative diseases: a mini review
X Yang, Z Ma, P Lian, Y Xu, X Cao - Frontiers in Molecular …, 2023 - frontiersin.org
Many neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis are characterized by the accumulation of pathogenic proteins …
amyotrophic lateral sclerosis are characterized by the accumulation of pathogenic proteins …
[HTML][HTML] Boosting peripheral BDNF rescues impaired in vivo axonal transport in CMT2D mice
Gain-of-function mutations in the housekee** gene GARS1, which lead to the expression
of toxic versions of glycyl-tRNA synthetase (GlyRS), cause the selective motor and sensory …
of toxic versions of glycyl-tRNA synthetase (GlyRS), cause the selective motor and sensory …
AAV-NRIP gene therapy ameliorates motor neuron degeneration and muscle atrophy in ALS model mice
HH Chen, HT Yeo, YH Huang, LK Tsai, HJ Lai… - Skeletal Muscle, 2024 - Springer
Background Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor
neuron (MN) degeneration, leading to neuromuscular junction (NMJ) dismantling and …
neuron (MN) degeneration, leading to neuromuscular junction (NMJ) dismantling and …
The secretome of human dental pulp stem cells and its components GDF15 and HB-EGF protect amyotrophic lateral sclerosis motoneurons against death
R Younes, Y Issa, N Jdaa, B Chouaib, V Brugioti… - Biomedicines, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a fatal and incurable paralytic disorder caused by the
progressive death of upper and lower motoneurons. Although numerous strategies have …
progressive death of upper and lower motoneurons. Although numerous strategies have …
[HTML][HTML] Brain-derived neurotrophic factor/tropomyosin receptor kinase B signaling in spinal muscular atrophy and amyotrophic lateral sclerosis
C Deng, H Chen - Neurobiology of Disease, 2024 - Elsevier
Tropomyosin receptor kinase B (TrkB) and its primary ligand brain-derived neurotrophic
factor (BDNF) are expressed in the neuromuscular system, where they affect neuronal …
factor (BDNF) are expressed in the neuromuscular system, where they affect neuronal …
[HTML][HTML] Neuromuscular organoids model spinal neuromuscular pathologies in C9orf72 amyotrophic lateral sclerosis
C Gao, Q Shi, X Pan, J Chen, Y Zhang, J Lang, S Wen… - Cell Reports, 2024 - cell.com
Hexanucleotide repeat expansions in the C9orf72 gene are the most common cause of
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Due to the lack of trunk …
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Due to the lack of trunk …
Bimodal regulation of axonal transport by the GDNF-RET signalling axis in healthy and diseased motor neurons
ER Rhymes, AP Tosolini, AD Fellows, W Mahy… - Cell Death & …, 2022 - nature.com
Deficits in axonal transport are one of the earliest pathological outcomes in several models
of amyotrophic lateral sclerosis (ALS), including SOD1G93A mice. Evidence suggests that …
of amyotrophic lateral sclerosis (ALS), including SOD1G93A mice. Evidence suggests that …
Neuromuscular junction denervation and terminal Schwann cell loss in the hTDP‐43 overexpression mouse model of amyotrophic lateral sclerosis
A Alhindi, M Shand, HL Smith, AS Leite… - Neuropathology and …, 2023 - Wiley Online Library
Aims Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with complex
aetiology. Despite evidence of neuromuscular junction (NMJ) denervation and 'dying …
aetiology. Despite evidence of neuromuscular junction (NMJ) denervation and 'dying …
Chemogenetic inhibition of TrkB signalling reduces phrenic motor neuron survival and size
Brain derived neurotrophic factor (BDNF) signalling through its high-affinity tropomyosin
receptor kinase B (TrkB) is known to have potent effects on motor neuron survival and …
receptor kinase B (TrkB) is known to have potent effects on motor neuron survival and …