Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

Transient receptor potential (TRP) channels are multifunctional signalling molecules with
many roles in sensory perception and cellular physiology. Therefore, it is not surprising that …

The glial cell of the peripheral nervous system (PNS), the Schwann cell (SC), counts among
the most multifaceted cells of the body. During development, SCs secure neuronal survival …

Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a
common chronic pain condition with major impact on quality of life. Examples include …

Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant
expansion and proliferation of macrophages around injured sensory neurons in dorsal root …

Efficacy of monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its
receptor (calcitonin receptor-like receptor/receptor activity modifying protein-1, CLR/RAMP1) …

The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

The perception of nociceptive signals, which are translated into pain, plays a fundamental
role in the survival of organisms. Because pain is linked to a negative sensation, animals …

Highlights•Macrophages induce pain via pro-inflammatory cytokines that activate
nociceptors.•Nociceptor neurons activate local macrophages via TLR signaling and CCL2 …

Introduction Chronic pain affects approximatively 30–50% of the population globally.
Pathologies such as migraine, diabetic neuropathy, nerve injury and treatment with …