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Pain-resolving immune mechanisms in neuropathic pain
Interactions between the immune and nervous systems are of central importance in
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …
Central sensitisation in chronic pain conditions: latest discoveries and their potential for precision medicine
Chronic pain is a leading cause of disability globally and associated with enormous health-
care costs. The discrepancy between the extent of tissue damage and the magnitude of …
care costs. The discrepancy between the extent of tissue damage and the magnitude of …
[HTML][HTML] The anatomy of pain and suffering in the brain and its clinical implications
Pain is an unpleasant sensory and emotional experience associated with actual or potential
tissue damage. Chronic pain, with a prevalence of 20–30% is the major cause of human …
tissue damage. Chronic pain, with a prevalence of 20–30% is the major cause of human …
Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities
Pain medication plays an important role in the treatment of acute and chronic pain
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …
Neuroinflammation and central sensitization in chronic and widespread pain
Chronic pain is maintained in part by central sensitization, a phenomenon of synaptic
plasticity and increased neuronal responsiveness in central pain pathways after painful …
plasticity and increased neuronal responsiveness in central pain pathways after painful …
Astrocytes in chronic pain and itch
Astrocytes are critical for maintaining the homeostasis of the CNS. Increasing evidence
suggests that a number of neurological and neuropsychiatric disorders, including chronic …
suggests that a number of neurological and neuropsychiatric disorders, including chronic …
Microglia in pain: detrimental and protective roles in pathogenesis and resolution of pain
The previous decade has seen a rapid increase in microglial studies on pain, with a unique
focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous …
focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous …
Migraine and neuroinflammation: the inflammasome perspective
Background Neuroinflammation has an important role in the pathophysiology of migraine,
which is a complex neuro-glio-vascular disorder. The main aim of this review is to highlight …
which is a complex neuro-glio-vascular disorder. The main aim of this review is to highlight …
Roles of inflammation, neurogenic inflammation, and neuroinflammation in pain
Inflammation is the body's response to injury and infection, involving a complex biological
response of the somatosensory, immune, autonomic, and vascular systems. Inflammatory …
response of the somatosensory, immune, autonomic, and vascular systems. Inflammatory …
Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential
Acute nociceptive pain is a key defence system that enables the detection of danger signals
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …