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The fidelity of cancer cells in PDX models: Characteristics, mechanism and clinical significance
Patient‐derived xenograft (PDX) models are widely used as preclinical cancer models and
are considered better than cell culture models in recapitulating the histological features …
are considered better than cell culture models in recapitulating the histological features …
Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells
BRCA1 deficiencies cause breast, ovarian, prostate and other cancers, and render tumours
hypersensitive to poly (ADP-ribose) polymerase (PARP) inhibitors. To understand the …
hypersensitive to poly (ADP-ribose) polymerase (PARP) inhibitors. To understand the …
Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes
Astrocytes play important roles in neurological disorders such as stroke, injury, and
neurodegeneration. Most knowledge on astrocyte biology is based on studies of mouse …
neurodegeneration. Most knowledge on astrocyte biology is based on studies of mouse …
Representation of genomic intratumor heterogeneity in multi-region non-small cell lung cancer patient-derived xenograft models
Patient-derived xenograft (PDX) models are widely used in cancer research. To investigate
the genomic fidelity of non-small cell lung cancer PDX models, we established 48 PDX …
the genomic fidelity of non-small cell lung cancer PDX models, we established 48 PDX …
Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology
Patient-based cancer models are essential tools for studying tumor biology and for the
assessment of drug responses in a translational context. We report the establishment a large …
assessment of drug responses in a translational context. We report the establishment a large …
A biobank of patient-derived pediatric brain tumor models
S Brabetz, SES Leary, SN Gröbner, MW Nakamoto… - Nature medicine, 2018 - nature.com
Brain tumors are the leading cause of cancer-related death in children. Genomic studies
have provided insights into molecular subgroups and oncogenic drivers of pediatric brain …
have provided insights into molecular subgroups and oncogenic drivers of pediatric brain …
Intraductal transplantation models of human pancreatic ductal adenocarcinoma reveal progressive transition of molecular subtypes
Pancreatic ductal adenocarcinoma (PDAC) is the most lethal common malignancy, with little
improvement in patient outcomes over the past decades. Recently, subtypes of pancreatic …
improvement in patient outcomes over the past decades. Recently, subtypes of pancreatic …
[HTML][HTML] FOXC2 promotes vasculogenic mimicry and resistance to anti-angiogenic therapy
Vasculogenic mimicry (VM) describes the formation of pseudo blood vessels constructed of
tumor cells that have acquired endothelial-like properties. VM channels endow the tumor …
tumor cells that have acquired endothelial-like properties. VM channels endow the tumor …
AL101, a gamma-secretase inhibitor, has potent antitumor activity against adenoid cystic carcinoma with activated NOTCH signaling
Adenoid cystic carcinoma (ACC) is an aggressive salivary gland malignancy with limited
treatment options for recurrent or metastatic disease. Due to chemotherapy resistance and …
treatment options for recurrent or metastatic disease. Due to chemotherapy resistance and …
Circadian dysfunction induces NAFLD-related human liver cancer in a mouse model
Background & Aims Chronic circadian dysfunction increases the risk of non-alcoholic fatty
liver disease (NAFLD)-related hepatocellular carcinoma (HCC), but the underlying …
liver disease (NAFLD)-related hepatocellular carcinoma (HCC), but the underlying …