Various diseases remain untreated due to lack of suitable therapeutic moiety or a suitable
drug delivery device, especially where toxicities and side effects are the primary reason for …

Cancer stem cells (CSC) are a distinct subpopulation within a tumor. They are able to self-
renew and differentiate and possess a high capability to repair DNA damage, exhibit low …

Immune checkpoint inhibitors have been successful across several tumor types; however,
their efficacy has been uncommon and unpredictable in glioblastomas (GBM), where< 10 …

High-grade glioma is one of the most aggressive types of cancer with a low survival rate
ranging from 12 to 15 months after the first diagnosis. Though being the most common …

An outstanding characteristic of gliomas is their infiltration into brain parenchyma, a property
that impairs complete surgical resection; consequently, these tumors might recur, resulting in …

Simple Summary As recurrence in glioblastoma is locally generated around the resection
cavity, surviving glioma stem-like cells may cause recurrence. Glioma stem-like cells …

Undesirable side effects and multidrug tolerance are the main holdbacks to the treatment of
cancer in conventional chemotherapy. Fortunately, targeted drug delivery can improve the …

Glioblastoma is characterized by diffuse infiltration into surrounding healthy brain tissues,
which makes it challenging to treat. Complete surgical resection is often impossible, and …

Rapid growth and perivascular invasion are hallmarks of glioblastoma (GBM) that have
been attributed to the presence of cancer stem-like cells (CSCs) and their association with …

Glioblastoma multiforme (GBM) is the most common and lethal type of brain tumor, and the
clinically available approaches for its treatment are not curative. Despite the intensive …