T cell receptor (TCR) signaling in health and disease
Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in
changes at the molecular and cellular levels in T cells. The outside environmental cues are …
changes at the molecular and cellular levels in T cells. The outside environmental cues are …
Mechanisms for T cell receptor triggering
PA Van Der Merwe, O Dushek - Nature Reviews Immunology, 2011 - nature.com
There is considerable controversy about the mechanism of T cell receptor (TCR) triggering,
the process by which the TCR tranduces signals across the plasma membrane after binding …
the process by which the TCR tranduces signals across the plasma membrane after binding …
Progresses in predicting post-translational modification
KC Chou - International Journal of Peptide Research and …, 2020 - Springer
Identification of the sites of post-translational modifications (PTMs) in protein, RNA, and DNA
sequences is currently a very hot topic. This is because the information thus obtained is very …
sequences is currently a very hot topic. This is because the information thus obtained is very …
Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling
H Zhang, SP Cordoba, O Dushek… - Proceedings of the …, 2011 - National Acad Sciences
The T-cell receptor (TCR) consists of a TCRαβ heterodimer, a TCRζ homodimer, and CD3γε
and CD3δε heterodimers. The precise mechanism of T-cell triggering following TCR ligand …
and CD3δε heterodimers. The precise mechanism of T-cell triggering following TCR ligand …
RAACBook: a web server of reduced amino acid alphabet for sequence-dependent inference by using Chou's five-step rule
By reducing amino acid alphabet, the protein complexity can be significantly simplified,
which could improve computational efficiency, decrease information redundancy and reduce …
which could improve computational efficiency, decrease information redundancy and reduce …
The TCR is an allosterically regulated macromolecular machinery changing its conformation while working
WW Schamel, B Alarcon, S Minguet - Immunological reviews, 2019 - Wiley Online Library
The αβ T‐cell receptor (TCR) is a multiprotein complex controlling the activation of T cells.
Although the structure of the complete TCR is not known, cumulative evidence supports that …
Although the structure of the complete TCR is not known, cumulative evidence supports that …
Identifying DNase I hypersensitive sites using multi-features fusion and F-score features selection via Chou's 5-steps rule
Y Liang, S Zhang - Biophysical Chemistry, 2019 - Elsevier
DNase I hypersensitive sites (DHSs) are regarded as those regions of chromatin that are
sensitive to cleavage by the DNase I enzyme. Identification of DNase I hypersensitive sites …
sensitive to cleavage by the DNase I enzyme. Identification of DNase I hypersensitive sites …
Impacts of pseudo amino acid components and 5-steps rule to proteomics and proteome analysis
KC Chou - Current topics in medicinal chemistry, 2019 - ingentaconnect.com
Stimulated by the 5-steps rule during the last decade or so, computational proteomics has
achieved remarkable progresses in the following three areas:(1) protein structural class …
achieved remarkable progresses in the following three areas:(1) protein structural class …
[HTML][HTML] Identifying FL11 subtype by characterizing tumor immune microenvironment in prostate adenocarcinoma via Chou's 5-steps rule
L Yang, Y Lv, S Wang, Q Zhang, Y Pan, D Su, Q Lu… - Genomics, 2020 - Elsevier
Prostate cancer is one of the leading causes of death in men worldwide, revealing a
substantial heterogeneity in terms of molecular and clinical behaviors. Tumor infiltrating …
substantial heterogeneity in terms of molecular and clinical behaviors. Tumor infiltrating …
Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor
T-cell receptor-CD3 complex (TCR) is a versatile signaling machine that can initiate antigen-
specific immune responses based on various biochemical changes of CD3 cytoplasmic …
specific immune responses based on various biochemical changes of CD3 cytoplasmic …