Loss of TMEM106B exacerbates Tau pathology and neurodegeneration in PS19 mice
T Feng, H Du, C Yang, Y Wang, F Hu - Acta Neuropathologica, 2024 - Springer
TMEM106B, a gene encoding a lysosome membrane protein, is tightly associated with brain
aging, hypomyelinating leukodystrophy, and multiple neurodegenerative diseases …
aging, hypomyelinating leukodystrophy, and multiple neurodegenerative diseases …
Similar brain proteomic signatures in Alzheimer's disease and epilepsy
The prevalence of epilepsy is increased among Alzheimer's Disease (AD) patients and
cognitive impairment is common among people with epilepsy. Epilepsy and AD are linked …
cognitive impairment is common among people with epilepsy. Epilepsy and AD are linked …
Big tau: what we know, and we need to know
I Fischer - eneuro, 2023 - eneuro.org
Tau is a microtubule-associated protein (MAP) that has multiple isoforms generated by
alternative splicing of the MAPT gene at a range of 45–60 kDa [low-molecular-weight (LMW) …
alternative splicing of the MAPT gene at a range of 45–60 kDa [low-molecular-weight (LMW) …
[HTML][HTML] Repurposing doxycycline for Alzheimer's treatment: Challenges from a nano-based drug delivery perspective
Drug repurposing, also known as drug repositioning, involves identifying new applications
for drugs whose effects in a disease are already established. Doxycycline, a broad-spectrum …
for drugs whose effects in a disease are already established. Doxycycline, a broad-spectrum …
Protein tau phosphorylation in the proline rich region and its implication in the progression of Alzheimer's disease
P Merino-Serrais, JM Soria, CA Arrabal… - Experimental …, 2025 - Elsevier
Tau has a wide variety of essential functions in the brain, but this protein also plays a
determining role in the development of Alzheimer's disease (AD) and other …
determining role in the development of Alzheimer's disease (AD) and other …
Tau and α-synuclein shape microtubule organization and microtubule-dependent transport in neuronal dendrites
Tau and α-synuclein are major players in neurodegenerative diseases, but their
physiological role, particularly in dendrites, is poorly understood. Here we show that …
physiological role, particularly in dendrites, is poorly understood. Here we show that …
Étude du rôle de la microglie dans la propagation de la protéine Tau: mise en place de nouveaux modèles
C Duwat - 2021 - theses.hal.science
La tauopathie, une caractéristique majeure de la maladie d'Alzheimer (MA), est due à
l'hyperphosphorylation et l'agrégation intra-neuronale de la protéine Tau. Au cours de la …
l'hyperphosphorylation et l'agrégation intra-neuronale de la protéine Tau. Au cours de la …