Colorectal cancer (CRC) is one of the most common aggressive carcinoma types worldwide,
characterized by unfavorable curative effect and poor prognosis. Epidemiological data re …

The insulin receptor (IR) gene undergoes differential splicing that generates two IR isoforms,
IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and …

Chronic non-communicable diseases are the major cause of death globally. Whole grains
are recommended in dietary guidelines worldwide due to increasing evidence that their …

The prevalence of obesity is rapidly increasing globally. Epidemiological studies have
associated obesity with a range of cancer types, although the mechanisms by which obesity …

This review examines the relationship between physical activity and cancer along the
cancer continuum, and serves as a synthesis of systematic and meta-analytic reviews …

The normal development and maintenance of the prostate is dependent on androgen acting
through the androgen receptor (AR). AR remains important in the development and …

This article reviews the biology, prevalence and risks for obesity in people and companion
dogs and cats, and explores the links between obesity and diabetes mellitus and cancer …

Background Insulin-like growth factor (IGF)-I and its main binding protein, IGFBP-3,
modulate cell growth and survival, and are thought to be important in tumour development …

This review focuses on the systemic complications of acromegaly. Mortality in this disease is
increased mostly because of cardiovascular and respiratory diseases, although currently …

Computational drug discovery is an effective strategy for accelerating and economizing drug
discovery and development process. Because of the dramatic increase in the availability of …