Vestibular hair cells and afferents: two channels for head motion signals

RA Eatock, JE Songer - Annual review of neuroscience, 2011 - annualreviews.org
Vestibular epithelia of the inner ear detect head motions over a wide range of amplitudes
and frequencies. In mammals, afferent nerve fibers from central and peripheral zones of …

Semicircular canal biomechanics in health and disease

RD Rabbitt - Journal of Neurophysiology, 2019 - journals.physiology.org
The semicircular canals are responsible for sensing angular head motion in three-
dimensional space and for providing neural inputs to the central nervous system (CNS) …

Evidence That Ultrafast Nonquantal Transmission Underlies Synchronized Vestibular Action Potential Generation

CJ Pastras, IS Curthoys, M Asadnia… - Journal of …, 2023 - Soc Neuroscience
Amniotes evolved a unique postsynaptic terminal in the inner ear vestibular organs called
the calyx that receives both quantal and nonquantal (NQ) synaptic inputs from Type I …

Characterization of spatial and temporal development of Type I and Type II hair cells in the mouse utricle using new cell-type-specific markers

S McInturff, JC Burns, MW Kelley - Biology open, 2018 - journals.biologists.com
The utricle of the inner ear, a vestibular sensory structure that mediates perception of linear
acceleration, is comprised of two morphologically and physiologically distinct types of …

Tuning and timing in mammalian type I hair cells and calyceal synapses

JE Songer, RA Eatock - Journal of Neuroscience, 2013 - Soc Neuroscience
Afferent nerve fibers in the central zones of vestibular epithelia form calyceal endings
around type I hair cells and have phasic response properties that emphasize fast head …

The potassium channel subunit KV1. 8 (Kcna10) is essential for the distinctive outwardly rectifying conductances of type I and II vestibular hair cells

HR Martin, A Lysakowski, RA Eatock - Elife, 2024 - elifesciences.org
In amniotes, head motions and tilt are detected by two types of vestibular hair cells (HCs)
with strikingly different morphology and physiology. Mature type I HCs express a large and …

Nonquantal transmission at the vestibular hair cell–calyx synapse: KLV currents modulate fast electrical and slow K+ potentials

AC Govindaraju, IH Quraishi… - Proceedings of the …, 2023 - National Acad Sciences
Vestibular hair cells transmit information about head position and motion across synapses to
primary afferent neurons. At some of these synapses, the afferent neuron envelopes the hair …

Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space

TA Babola, CJ Kersbergen, HC Wang, DE Bergles - Elife, 2020 - elifesciences.org
Neurons in develo** sensory pathways exhibit spontaneous bursts of electrical activity
that are critical for survival, maturation and circuit refinement. In the auditory system …

A review of mechanical and synaptic processes in otolith transduction of sound and vibration for clinical VEMP testing

IS Curthoys, JW Grant, CJ Pastras… - Journal of …, 2019 - journals.physiology.org
Older studies of mammalian otolith physiology have focused mainly on sustained responses
to low-frequency (< 50 Hz) or maintained linear acceleration. So the otoliths have been …

Phase-locking of irregular guinea pig primary vestibular afferents to high frequency (> 250 Hz) sound and vibration

IS Curthoys, AM Burgess, SC Goonetilleke - Hearing Research, 2019 - Elsevier
Phase-locking of cochlear neurons to sound has been of great value in understanding
cochlear transduction. Phase-locking has also been reported previously in irregular …