Antibodies are versatile molecular binders with an established and growing role as
therapeutics. Computational approaches to develo** and designing these molecules are …

Antibodies are proteins that recognize the molecular surfaces of potentially noxious
molecules to mount an adaptive immune response or, in the case of autoimmune diseases …

B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …

Antibody-antigen binding relies on the specific interaction of amino acids at the paratope-
epitope interface. The predictability of antibody-antigen binding is a prerequisite for de novo …

Therapeutic monoclonal antibodies and their derivatives are key components of clinical
pipelines in the global biopharmaceutical industry. The availability of large datasets of …

The origins of the various elements in the human antibody repertoire have been and still are
subject to considerable uncertainty. Uncertainty in respect of whether the various elements …

Antibodies are vital proteins of the immune system that recognize potentially harmful
molecules and initiate their removal. Mammals can efficiently create vast numbers of …

B cells play a central role in adaptive immune processes, mainly through the production of
antibodies. The maturation of the B cell system with age is poorly studied. We extensively …

The adaptive immune system is a natural diagnostic sensor and therapeutic. It recognizes
threats earlier than clinical symptoms manifest and neutralizes antigens with exquisite …

AlphaFold2 has hallmarked a generational improvement in protein structure prediction. In
particular, advances in antibody structure prediction have provided a highly translatable …