Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Lysine acetylation is a conserved protein post-translational modification that links acetyl-
coenzyme A metabolism and cellular signalling. Recent advances in the identification and …

Cellular functions are governed by molecular machines that assemble through protein-
protein interactions. Their atomic details are critical to studying their molecular mechanisms …

Protein phosphorylation is a key post-translational modification regulating protein function in
almost all cellular processes. Although tens of thousands of phosphorylation sites have …

INTRODUCTION MicroRNAs (miRNAs) are a class of highly conserved small regulatory
RNAs. After loading into Argonaute (AGO) proteins, miRNAs promote the degradation and …

Regulatory protein phosphorylation controls normal and pathophysiological signaling in
eukaryotic cells. Despite great advances in mass-spectrometry-based proteomics, the …

Post-translational modification (PTM) of proteins allows cells to regulate protein functions,
transduce signals and respond to perturbations. PTMs expand protein functionality and …

Cross-talk between different types of post-translational modifications on the same protein
molecule adds specificity and combinatorial logic to signal processing, but it has not been …

A molecular description of functional modules in the cell is the focus of many high-
throughput studies in the postgenomic era. A large portion of biomolecular interactions in …

The eukaryotic cell is a bustling collection of macromolecules acting cooperatively to
mediate the functions required for cell viability. Specific, context-dependent and tightly …