The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human
epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene …

Cells are continuously exposed to diverse stimuli ranging from soluble endocrine and
paracrine factors, to signaling molecules on neighboring cells. It is of great importance that …

Activated EGFR signalling drives tumorigenicity in 50% of glioblastoma (GBM). However,
EGFR-targeting therapy has proven ineffective in treating patients with GBM, indicating that …

The epidermal growth factor receptor (EGFR) signaling pathway is one of the most important
pathways that regulate growth, survival, proliferation, and differentiation in mammalian cells …

A novel potential cell surface receptor of the tyrosine kinase gene family has been identified
and characterized by molecular cloning. Its primary sequence is very similar to that of the …

Growth factors, a diverse group of polypeptides that modify cell proliferation, constitute a
distinct subgroup in endocrinology. The biology of these factors differs somewhat from …

Phosphoryl transfer plays key roles in signaling, energy transduction, protein synthesis, and
maintaining the integrity of the genetic material. On the surface, it would appear to be a …

The activation of STAT3 by tyrosine phosphorylation, essential for normal development and
for a normal inflammatory response to invading pathogens, is kept in check by negative …

Structural features of v‐kit, the oncogene of HZ4 feline sarcoma virus, suggested that this
gene arose by transduction and truncation of cellular sequences. Complementary DNA …

We have deduced the entire 1,370-amino-acid sequence of the human insulin receptor
precursor from a single complementary DNA clone. The precursor starts with a 27-amino …