The prevalence of obesity has tripled over the past four decades, imposing an enormous
burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset …

Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …

We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we
report the human gut microbial composition in a population sample of 123 non-obese and …

Background Genomewide association studies can be used to identify disease-relevant
genomic regions, but interpretation of the data is challenging. The FTO region harbors the …

Abstract Summary The Avon Longitudinal Study of Children and Parents (ALSPAC) was
established to understand how genetic and environmental characteristics influence health …

Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …

INTRODUCTION Obesity accounts for a substantial and growing burden of disease globally.
Body adiposity is highly heritable, and human genetic studies can lead to biological and …

Genome-wide association studies (GWAS) have revealed hundreds of loci associated with
common human genetic diseases and traits. We have developed a web-based plotting tool …

To extend understanding of the genetic architecture and molecular basis of type 2 diabetes
(T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including …

Host genetics are known to influence the gut microbiome, yet their role remains poorly
understood. To robustly characterize these effects, we performed a genome-wide …