Alternative mRNA transcription, processing, and translation: insights from RNA sequencing

E de Klerk, P AC't Hoen - Trends in Genetics, 2015 - cell.com
The human transcriptome comprises> 80000 protein-coding transcripts and the estimated
number of proteins synthesized from these transcripts is in the range of 250000 to 1 million …

SWATH‐MS as a tool for biomarker discovery: From basic research to clinical applications

SI Anjo, C Santa, B Manadas - Proteomics, 2017 - Wiley Online Library
In the era of quantitative proteomics, where mass spectrometry plays a pivotal role, in
particular associated with the use of data‐independent acquisition, it is time to perform an …

Guide for protein fold change and p-value calculation for non-experts in proteomics

JT Aguilan, K Kulej, S Sidoli - Molecular omics, 2020 - pubs.rsc.org
Proteomics studies generate tables with thousands of entries. A significant component of
being a proteomics scientist is the ability to process these tables to identify regulated …

The application of mesoporous silica nanoparticle family in cancer theranostics

Y Feng, N Panwar, DJH Tng, SC T**, K Wang… - Coordination chemistry …, 2016 - Elsevier
Cancer is among the most serious diseases characterized by uncontrollable cell growth and
spread of abnormal cells. Cancerous cells form tumors that negatively impact the functions …

Multiomics technologies: role in disease biomarker discoveries and therapeutics

MA Dar, A Arafah, KA Bhat, A Khan… - Briefings in …, 2023 - academic.oup.com
Medical research has been revolutionized after the publication of the full human genome.
This was the major landmark that paved the way for understanding the biological functions …

Molecular elucidation of disease biomarkers at the interface of chemistry and biology

L Zhang, S Wan, Y Jiang, Y Wang, T Fu… - Journal of the …, 2017 - ACS Publications
Disease-related biomarkers are objectively measurable molecular signatures of
physiological status that can serve as disease indicators or drug targets in clinical diagnosis …

Proteomics and its current application in biomedical area: Concise review

S Gobena, B Admassu, MZ Kinde… - The Scientific World …, 2024 - Wiley Online Library
Biomedical researchers tirelessly seek cutting‐edge technologies to advance disease
diagnosis, drug discovery, and therapeutic interventions, all aimed at enhancing human and …

Label-based and label-free strategies for protein quantitation

S Anand, M Samuel, CS Ang, S Keerthikumar… - Proteome …, 2017 - Springer
The precise quantification of changes between various physiological states in a biological
system is highly complex in nature. Over the past few years, in combination with classical …

[HTML][HTML] Mesoporous silica nanomaterials: versatile nanocarriers for cancer theranostics and drug and gene delivery

S Kesse, KO Boakye-Yiadom, BO Ochete… - Pharmaceutics, 2019 - mdpi.com
Mesoporous silica nanomaterials (MSNs) have made remarkable achievements and are
being thought of by researchers as materials that can be used to effect great change in …