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Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …
Control of immunity by the microbiota
The immune system has coevolved with extensive microbial communities living on barrier
sites that are collectively known as the microbiota. It is increasingly clear that microbial …
sites that are collectively known as the microbiota. It is increasingly clear that microbial …
The biology and functional importance of MAIT cells
In recent years, a population of unconventional T cells called 'mucosal-associated invariant
T cells'(MAIT cells) has captured the attention of immunologists and clinicians due to their …
T cells'(MAIT cells) has captured the attention of immunologists and clinicians due to their …
MAIT cells are imprinted by the microbiota in early life and promote tissue repair
INTRODUCTION The microbiota promotes the maturation and homeostasis of the immune
system, in part through the release of microbial products. Early-life microbial colonization …
system, in part through the release of microbial products. Early-life microbial colonization …
Innate lymphoid cells and innate-like T cells in cancer—at the crossroads of innate and adaptive immunity
Immunotherapies targeting conventional T cells have revolutionized systemic treatment for
many cancers, yet only a subset of patients benefit from these approaches. A better …
many cancers, yet only a subset of patients benefit from these approaches. A better …
Thymic development of unconventional T cells: how NKT cells, MAIT cells and γδ T cells emerge
T cell lineages are defined by specialized functions and differential expression of surface
antigens, cytokines and transcription factors. Conventional CD4+ and CD8+ T cells are the …
antigens, cytokines and transcription factors. Conventional CD4+ and CD8+ T cells are the …
Guidelines for the use of flow cytometry and cell sorting in immunological studies
These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …
immunology and flow cytometry community. They provide the theory and key practical …
The role of gut microbiota in T cell immunity and immune mediated disorders
Gut microbiota was only considered as a commensal organism that aids in digestion, but
recent studies revealed that the microbiome play a critical role in both physiological and …
recent studies revealed that the microbiome play a critical role in both physiological and …
B vitamins and their role in immune regulation and cancer
B group vitamins represent essential micronutrients for myriad metabolic and regulatory
processes required for human health, serving as cofactors used by hundreds of enzymes …
processes required for human health, serving as cofactors used by hundreds of enzymes …
Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognize microbial
metabolites through a semi-invariant T cell receptor (TCR). Major questions remain …
metabolites through a semi-invariant T cell receptor (TCR). Major questions remain …