Natural products have served as powerful therapeutics against pathogenic bacteria since
the golden age of antibiotics of the mid-20th century. However, the increasing frequency of …

Macrocyclic structures are common synthetic targets in drug discovery,(1, 2) and therefore,
interest in their study is continuously increasing in this field.(3, 4) A classic example is …

The discovery and implementation of antibiotics in the early twentieth century transformed
human health and wellbeing. Chemical synthesis enabled the development of the first …

The chemical modification of structurally complex fermentation products, a process known
as semisynthesis, has been an important tool in the discovery and manufacture of antibiotics …

The advent of modern antibiotics contributed enormously to the dramatic extension of
human lifespan since their discovery by virtue of their lethal and selective action against …

Ever since the first isolation of Exaltolide 1 (Figure 1) in 1927 by Kerschbaum, 1 interest in
macrocyclic lactones, defined as lactones with more than 8 atoms in the ring, has been …

For a long time, the synthesis of quinine constituted an elusive target. In 2004, which marked
the 60th anniversary of the publication of the approach used by Woodward and Doering to …

1. INTRODUCTION Ever since the first isolation of Exaltolide 1 (Figure 1) in 1927 by
Kerschbaum, 1 interest in macrocyclic lactones, defined as lactones with more than 8 atoms …

DNA-templated organic synthesis enables the translation, selection, and amplification of
DNA sequences encoding synthetic small-molecule libraries. Previously we described the …

Macrocycles are key structural elements in numerous bioactive small molecules and are
attractive targets in the diversity-oriented synthesis of natural product–based libraries …