Polymersome-based protein drug delivery–quo vadis?

MG Gouveia, JP Wesseler, J Ramaekers… - Chemical Society …, 2023 - pubs.rsc.org
Protein-based therapeutics are an attractive alternative to established therapeutic
approaches and represent one of the fastest growing families of drugs. While many of these …

Fluid protein condensates for bio-inspired applications

MJ Harrington, R Mezzenga, A Miserez - Nature Reviews …, 2024 - nature.com
Since the discovery of tropoelastin liquid–liquid phase separation in the 1950s, it has been
recognized that fluid protein condensates, including coacervates and liquid crystals, are …

Phase-separating peptides for direct cytosolic delivery and redox-activated release of macromolecular therapeutics

Y Sun, SY Lau, ZW Lim, SC Chang, F Ghadessy… - Nature Chemistry, 2022 - nature.com
Biomacromolecules are highly promising therapeutic modalities to treat various diseases.
However, they suffer from poor cellular membrane permeability, limiting their access to …

Cellular trafficking of nanotechnology‐mediated mRNA delivery

P Huang, H Deng, C Wang, Y Zhou… - Advanced …, 2024 - Wiley Online Library
Messenger RNA (mRNA)‐based therapy has emerged as a powerful, safe, and rapidly
scalable therapeutic approach that involves technologies for both mRNA itself and the …

Reversible assembly of proteins and phenolic polymers for intracellular protein delivery with serum stability

G Rong, X Zhou, J Hong, Y Cheng - Nano Letters, 2024 - ACS Publications
The design of intracellular delivery systems for protein drugs remains a challenge due to
limited delivery efficacy and serum stability. Herein, we propose a reversible assembly …
A Ahmad, JM Khan, BA Paray, K Rashid, A Parvez - Drug Discovery Today, 2024 - Elsevier
Internalizing therapeutic molecules or genes into cells and safely delivering them to the
target tissue where they can perform the intended tasks is one of the key characteristics of …