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Polymersome-based protein drug delivery–quo vadis?
Protein-based therapeutics are an attractive alternative to established therapeutic
approaches and represent one of the fastest growing families of drugs. While many of these …
approaches and represent one of the fastest growing families of drugs. While many of these …
Fluid protein condensates for bio-inspired applications
Since the discovery of tropoelastin liquid–liquid phase separation in the 1950s, it has been
recognized that fluid protein condensates, including coacervates and liquid crystals, are …
recognized that fluid protein condensates, including coacervates and liquid crystals, are …
Phase-separating peptides for direct cytosolic delivery and redox-activated release of macromolecular therapeutics
Biomacromolecules are highly promising therapeutic modalities to treat various diseases.
However, they suffer from poor cellular membrane permeability, limiting their access to …
However, they suffer from poor cellular membrane permeability, limiting their access to …
Cellular trafficking of nanotechnology‐mediated mRNA delivery
P Huang, H Deng, C Wang, Y Zhou… - Advanced …, 2024 - Wiley Online Library
Messenger RNA (mRNA)‐based therapy has emerged as a powerful, safe, and rapidly
scalable therapeutic approach that involves technologies for both mRNA itself and the …
scalable therapeutic approach that involves technologies for both mRNA itself and the …
Reversible assembly of proteins and phenolic polymers for intracellular protein delivery with serum stability
G Rong, X Zhou, J Hong, Y Cheng - Nano Letters, 2024 - ACS Publications
The design of intracellular delivery systems for protein drugs remains a challenge due to
limited delivery efficacy and serum stability. Herein, we propose a reversible assembly …
limited delivery efficacy and serum stability. Herein, we propose a reversible assembly …
A Ahmad, JM Khan, BA Paray, K Rashid, A Parvez - Drug Discovery Today, 2024 - Elsevier
Internalizing therapeutic molecules or genes into cells and safely delivering them to the
target tissue where they can perform the intended tasks is one of the key characteristics of …
target tissue where they can perform the intended tasks is one of the key characteristics of …