MalaCards: an amalgamated human disease compendium with diverse clinical and genetic annotation and structured search

N Rappaport, M Twik, I Plaschkes, R Nudel… - Nucleic acids …, 2017 - academic.oup.com
The MalaCards human disease database (http://www. malacards. org/) is an integrated
compendium of annotated diseases mined from 68 data sources. MalaCards has a web card …

The genecards suite

M Safran, N Rosen, M Twik, R BarShir, TI Stein… - Practical guide to life …, 2021 - Springer
The GeneCards® database of human genes was launched in 1997 and has expanded
since then to encompass gene-centric, disease-centric, and pathway-centric entities and …

GeneHancer: genome-wide integration of enhancers and target genes in GeneCards

S Fishilevich, R Nudel, N Rappaport, R Hadar… - Database, 2017 - academic.oup.com
A major challenge in understanding gene regulation is the unequivocal identification of
enhancer elements and uncovering their connections to genes. We present GeneHancer, a …

The GeneCards suite: from gene data mining to disease genome sequence analyses

G Stelzer, N Rosen, I Plaschkes… - Current protocols in …, 2016 - Wiley Online Library
GeneCards, the human gene compendium, enables researchers to effectively navigate and
inter‐relate the wide universe of human genes, diseases, variants, proteins, cells, and …

In Silico Toxicology Data Resources to Support Read-Across and (Q)SAR

G Pawar, JC Madden, D Ebbrell, JW Firman… - Frontiers in …, 2019 - frontiersin.org
A plethora of databases exist online that can assist in in silico chemical or drug safety
assessment. However, a systematic review and grou** of databases, based on purpose …

Genome-wide analysis of somatic noncoding mutation patterns in cancer

F Dietlein, AB Wang, C Fagre, A Tang, NJM Besselink… - Science, 2022 - science.org
We established a genome-wide compendium of somatic mutation events in 3949 whole
cancer genomes representing 19 tumor types. Protein-coding events captured well …

Xenbase: a genomic, epigenomic and transcriptomic model organism database

K Karimi, JD Fortriede, VS Lotay, KA Burns… - Nucleic acids …, 2018 - academic.oup.com
Abstract Xenbase (www. xenbase. org) is an online resource for researchers utilizing
Xenopus laevis and Xenopus tropicalis, and for biomedical scientists seeking access to data …

GeneAnalytics: an integrative gene set analysis tool for next generation sequencing, RNAseq and microarray data

S Ben-Ari Fuchs, I Lieder, G Stelzer… - Omics: a journal of …, 2016 - liebertpub.com
Postgenomics data are produced in large volumes by life sciences and clinical applications
of novel omics diagnostics and therapeutics for precision medicine. To move from “data-to …

VarElect: the phenotype-based variation prioritizer of the GeneCards Suite

G Stelzer, I Plaschkes, D Oz-Levi, A Alkelai, T Olender… - BMC genomics, 2016 - Springer
Background Next generation sequencing (NGS) provides a key technology for deciphering
the genetic underpinnings of human diseases. Typical NGS analyses of a patient depict tens …

Mouse aging cell atlas analysis reveals global and cell type-specific aging signatures

MJ Zhang, AO Pisco, S Darmanis, J Zou - Elife, 2021 - elifesciences.org
Aging is associated with complex molecular and cellular processes that are poorly
understood. Here we leveraged the Tabula Muris Senis single-cell RNA-seq data set to …