Roles of intestinal Parabacteroides in human health and diseases

Y Cui, L Zhang, X Wang, Y Yi, Y Shan… - FEMS microbiology …, 2022 - academic.oup.com
The stability of gut microbiota is essential for the host's health. Parabacteroides spp., core
members of the human gut microbiota, have an average abundance of 1.27% in humans of …

Parabacteroides distasonis: intriguing aerotolerant gut anaerobe with emerging antimicrobial resistance and pathogenic and probiotic roles in human health

JC Ezeji, DK Sarikonda, A Hopperton, HL Erkkila… - Gut …, 2021 - Taylor & Francis
Parabacteroides distasonis is the type strain for the genus Parabacteroides, a group of gram-
negative anaerobic bacteria that commonly colonize the gastrointestinal tract of numerous …

Parabacteroides distasonis alleviates obesity and metabolic dysfunctions via production of succinate and secondary bile acids

K Wang, M Liao, N Zhou, L Bao, K Ma, Z Zheng… - Cell reports, 2019 - cell.com
We demonstrated the metabolic benefits of Parabacteroides distasonis (PD) on decreasing
weight gain, hyperglycemia, and hepatic steatosis in ob/ob and high-fat diet (HFD)-fed mice …

[HTML][HTML] Whole-virome analysis sheds light on viral dark matter in inflammatory bowel disease

AG Clooney, TDS Sutton, AN Shkoporov, RK Holohan… - Cell host & …, 2019 - cell.com
The human gut virome is thought to significantly impact the microbiome and human health.
However, most virome analyses have been performed on a limited fraction of known viruses …

Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models

E Cekanaviciute, BB Yoo, TF Runia… - Proceedings of the …, 2017 - National Acad Sciences
The gut microbiota regulates T cell functions throughout the body. We hypothesized that
intestinal bacteria impact the pathogenesis of multiple sclerosis (MS), an autoimmune …

[HTML][HTML] Linking the human gut microbiome to inflammatory cytokine production capacity

M Schirmer, SP Smeekens, H Vlamakis, M Jaeger… - Cell, 2016 - cell.com
Gut microbial dysbioses are linked to aberrant immune responses, which are often
accompanied by abnormal production of inflammatory cytokines. As part of the Human …

Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy

A Abdel-Gadir, E Stephen-Victor, GK Gerber… - Nature medicine, 2019 - nature.com
The role of dysbiosis in food allergy (FA) remains unclear. We found that dysbiotic fecal
microbiota in FA infants evolved compositionally over time and failed to protect against FA in …

Probiotics modulated gut microbiota suppresses hepatocellular carcinoma growth in mice

J Li, CYJ Sung, N Lee, Y Ni… - Proceedings of the …, 2016 - National Acad Sciences
The beneficial roles of probiotics in lowering the gastrointestinal inflammation and
preventing colorectal cancer have been frequently demonstrated, but their …

Obesity and cancer: inflammation bridges the two

R Kolb, FS Sutterwala, W Zhang - Current opinion in pharmacology, 2016 - Elsevier
Highlights•Obesity is associated with chronic inflammation and chronic diseases.•Obesity is
associated with increased risk and progression of several cancers.•The mechanism by …

The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide

S Viaud, F Saccheri, G Mignot, T Yamazaki, R Daillère… - science, 2013 - science.org
Cyclophosphamide is one of several clinically important cancer drugs whose therapeutic
efficacy is due in part to their ability to stimulate antitumor immune responses. Studying …