Formate may become an ideal mediator between the physicochemical and biological
realms, as it can be produced efficiently from multiple available sources, such as electricity …

Covalent inhibitors have been a rapidly growing field in drug discovery due to their
therapeutic potential and unique advantages in cancer therapy. As opposed to noncovalent …

Amino Acid Metabolism, 3rd Edition covers all aspects of the biochemistry and nutritional
biochemistry of the amino acids. Starting with an overview of nitrogen fixation and the …

δ-aminolevulinate (ALA) is an important intermediate involved in tetrapyrrole synthesis
(precursor for vitamin B12, chlorophyll and heme) in vivo. It has been widely applied in …

Biotin (vitamin H) is one of the most fascinating cofactors involved in central pathways in pro-
and eukaryotic cell metabolism. Since its original discovery in 1901, research has led to the …

5‐Aminolevulinate synthase (ALAS) is the first and rate‐limiting enzyme of heme
biosynthesis in humans, animals, other non‐plant eukaryotes, and α‐proteobacteria. It …

Pyridoxal 5′-phosphate enzymes are ubiquitous in the nitrogen metabolism of all
organisms. They catalyze a wide variety of reactions including racemization, transamination …

Metabolism plays a significant role in the regulation of aging at different levels, and
metabolic reprogramming represents a major driving force in aging. Metabolic …

Sphingolipids (SLs) are essential components of cellular membranes formed from the
condensation of l-serine and a long-chain acyl thioester. This first step is catalyzed by the …

Sphingolipid biosynthesis commences with the condensation of L-serine and palmitoyl-CoA
to produce 3-ketodihydrosphingosine (KDS). This reaction is catalysed by the PLP …