Large, elastic arteries are composed of cells and a specialized extracellular matrix that
provides reversible elasticity and strength. Elastin is the matrix protein responsible for this …

The stiffness and structural integrity of the arterial wall depends primarily on the organization
of the extracellular matrix and the cells that fashion and maintain this matrix. Fundamental to …

This review discusses sexual dimorphism in arterial stiffening, disease pathology
interactions, and the influence of sex on mechanisms and pathways. Arterial stiffness …

Through mechanobiological control of the extracellular matrix, and hence local stiffness,
smooth muscle cells of the media and fibroblasts of the adventitia play important roles in …

Gradual collagen recruitment has been hypothesized as the underlying mechanism for the
mechanical stiffening with increasing stress in arteries. In this work, we investigated this …

Aims Elastin is the primary component of elastic fibres in arteries, which contribute
significantly to the structural integrity of the wall. Fibrillin-1 is a microfibrillar glycoprotein that …

Central artery stiffness has emerged over the past 15 years as a clinically significant
indicator of cardiovascular function and initiator of disease. Loss of elastic fiber integrity is …

The evolving microstructure and mechanical properties that promote homeostasis in the
aorta are fundamental to age-specific adaptations and disease progression. We combine ex …

Introduction Nutritional support is potentially considered an essential step to prevent muscle
loss and enhance physical function in older adults. Objectives This study aimed to assess …

Increased arterial stiffness and blood pressure are characteristic of humans and adult mice
with reduced elastin levels caused by aging or genetic disease. Direct associations have …