Almost 60 years have passed since the initial discovery by Hubel and Wiesel that changes
in neuronal activity can elicit developmental rewiring of the central nervous system (CNS) …

In a neural circuit, synapses transfer information rapidly between neurons and transform this
information during transfer. The diverse computational properties of synapses are shaped by …

Decades of research in skeletal muscle physiology have provided multiscale insights into
the structural and functional complexity of this important anatomical tissue, designed to …

Synapses are intercellular junctions specialized for fast, point-to-point information transfer
from a presynaptic neuron to a postsynaptic cell. At a synapse, a presynaptic terminal …

Abstract The complement component 4 (C4) gene is linked to schizophrenia and synaptic
refinement. In humans, greater expression of C4A in the brain is associated with an …

Neuromuscular networks assemble during early human embryonic development and are
essential for the control of body movement. Previous neuromuscular junction modeling …

Skeletal muscle is the largest tissue in the body and loss of its function or its regenerative
properties results in debilitating musculoskeletal disorders. Understanding the mechanisms …

The study of botulinum neurotoxins (BoNT) is rapidly progressing in many aspects. Novel
BoNTs are being discovered owing to next generation sequencing, but their biologic and …

Amyotrophic lateral sclerosis (ALS), the major adult-onset motor neuron disease, has been
viewed almost exclusively as a disease of upper and lower motor neurons, with muscle …

The development of neural interfaces with superior biocompatibility and improved tissue
integration is vital for treating and restoring neurological functions in the nervous system. A …