Several promising strategies based on combining or cycling different antibiotics have been
proposed to increase efficacy and counteract resistance evolution, but we still lack a deep …

Highlights•Bacterial communities survive antimicrobial therapy where individuals
cannot.•This effect can be produced by cooperative inactivation of antibiotics.•Biofilms …

Paneth cells are the primary source of C-type lysozyme, a β-1, 4-N-
acetylmuramoylhydrolase that enzymatically processes bacterial cell walls. Paneth cells are …

Antibiotic resistance can be acquired by mutation or horizontal transfer of a resistance gene,
and generally an acquired mechanism results in a predictable increase in phenotypic …

Bacteria are single-celled organisms, but the survival of microbial communities relies on
complex dynamics at the molecular, cellular, and ecosystem scales. Antibiotic resistance, in …

Inactivation of β‐lactam antibiotics by resistant bacteria is a 'cooperative'behavior that may
allow sensitive bacteria to survive antibiotic treatment. However, the factors that determine …

Gene circuits are dynamical systems that regulate cellular behaviors, often using protein
signals as inputs and outputs. Here we have developed an optogenetic'function …

The rise of antibiotic resistance is a threat to global health. Rapid and comprehensive
analysis of infectious strains is critical to reducing the global use of antibiotics, as informed …

Bacteria have developed resistance against every antibiotic at a rate that is alarming
considering the timescale at which new antibiotics are developed. Thus, there is a critical …

Introduction Understanding how bacteria harboring antibiotic resistance grow in the
presence of antibiotics is critical for predicting the spread and evolution of drug resistance …