Mechanosensation and adaptive motor control in insects

JC Tuthill, RI Wilson - Current Biology, 2016 - cell.com
The ability of animals to flexibly navigate through complex environments depends on the
integration of sensory information with motor commands. The sensory modality most tightly …

[HTML][HTML] Multilevel visuomotor control of locomotion in Drosophila

TL Cruz, ME Chiappe - Current Opinion in Neurobiology, 2023 - Elsevier
Vision is critical for the control of locomotion, but the underlying neural mechanisms by
which visuomotor circuits contribute to the movement of the body through space are yet not …

[HTML][HTML] Reconstruction of motor control circuits in adult Drosophila using automated transmission electron microscopy

JS Phelps, DGC Hildebrand, BJ Graham, AT Kuan… - Cell, 2021 - cell.com
To investigate circuit mechanisms underlying locomotor behavior, we used serial-section
electron microscopy (EM) to acquire a synapse-resolution dataset containing the ventral …

Ascending neurons convey behavioral state to integrative sensory and action selection brain regions

CL Chen, F Aymanns, R Minegishi, VDV Matsuda… - Nature …, 2023 - nature.com
Knowing one's own behavioral state has long been theorized as critical for contextualizing
dynamic sensory cues and identifying appropriate future behaviors. Ascending neurons …

Dopamine promotes head direction plasticity during orienting movements

YE Fisher, M Marquis, I D'Alessandro, RI Wilson - Nature, 2022 - nature.com
In neural networks that store information in their connection weights, there is a tradeoff
between sensitivity and stability,. Connections must be plastic to incorporate new …

Flexible neural control of transition points within the egg-laying behavioral sequence in Drosophila

KM Cury, R Axel - Nature Neuroscience, 2023 - nature.com
Innate behaviors are frequently comprised of ordered sequences of component actions that
progress to satisfy essential drives. Progression is governed by specialized sensory cues …

Dense neuronal reconstruction through X-ray holographic nano-tomography

AT Kuan - Biophysical Journal, 2020 - cell.com
1416-Pos Modulation of Human Stem Cell Derived Neuron Activity through Addition of an
External Conductance using Dynamic Clamp Brian K. Panama1, Leigh Korbel1, Brandon …

[HTML][HTML] A single-cell transcriptomic atlas of the adult Drosophila ventral nerve cord

AM Allen, MC Neville, S Birtles, V Croset, CD Treiber… - Elife, 2020 - elifesciences.org
The Drosophila ventral nerve cord (VNC) receives and processes descending signals from
the brain to produce a variety of coordinated locomotor outputs. It also integrates sensory …

Molecular sensing of mechano-and ligand-dependent adhesion GPCR dissociation

N Scholz, AK Dahse, M Kemkemer, A Bormann… - Nature, 2023 - nature.com
Adhesion G-protein-coupled receptors (aGPCRs) bear notable similarity to Notch proteins, a
class of surface receptors poised for mechano-proteolytic activation,–, including an …

Systematic annotation of a complete adult male Drosophila nerve cord connectome reveals principles of functional organisation

EC Marin, BJ Morris, T Stürner, AS Champion… - BioRxiv, 2023 - biorxiv.org
Our companion paper introduces the first completely proofread connectome of the nerve
cord of an animal that can walk or fly. The base connectome consists of neuronal …