Limonoids from neem (Azadirachta indica A. Juss.) are potential anticancer drug candidates

S Nagini, M Palrasu, A Bishayee - Medicinal research reviews, 2024 - Wiley Online Library
Abstract Neem (Azadirachta indica A. Juss.), a versatile evergreen tree recognized for its
ethnopharmacological value, is a rich source of limonoids of the triterpenoid class, endowed …

Biological activities of gedunin—A limonoid from the Meliaceae family

TM Braga, L Rocha, TY Chung, RF Oliveira, C Pinho… - Molecules, 2020 - mdpi.com
Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly
in seeds. Several biological activities have been attributed to gedunin, including …

Anthraquinone derivatives as an immune booster and their therapeutic option against COVID-19

P Khanal, BM Patil, J Chand, Y Naaz - Natural products and …, 2020 - Springer
Anthraquinone derivatives are identified for their immune-boosting, anti-inflammatory, and
anti-viral efficacy. Hence, the present study aimed to investigate the reported anthraquinone …

[HTML][HTML] A network pharmacology approach with experimental validation to discover protective mechanism of poly herbal extract on diabetes mellitus

AK Singh, P Kumar, SK Mishra, KN Tiwari… - Journal of King Saud …, 2024 - Elsevier
Objective Polyherbal extracts (PHE) contain six traditional medicinal plants, and the efficacy
of the medicinal plants used in the preparation of this PHE has been confirmed for the …

[HTML][HTML] In vitro and in silico anti-oxidant, cytotoxicity and biological activities of Ficus benghalensis and Duranta repens

P Khanal, BM Patil - Chinese Herbal Medicines, 2020 - Elsevier
Objective To report in vitro anti-oxidant activity and cytotoxicity of hydroalcoholic extract of
Ficus benghalensis (bark) and Duranta repens (whole plant), and present the probable …

[HTML][HTML] In silico discovery of 3 novel quercetin derivatives against papain-like protease, spike protein, and 3C-like protease of SARS-CoV-2

K Bhattacharya, R Bordoloi, NR Chanu, R Kalita… - Journal of Genetic …, 2022 - Elsevier
Background The derivatives of quercetin is known for their immune-modulating antiviral, anti-
blood clotting, antioxidant, and also for its anti-inflammatory efficacy. The current study was …

Integration of network and experimental pharmacology to decipher the antidiabetic action of Duranta repens L.

P Khanal, BM Patil - Journal of Integrative Medicine, 2021 - Elsevier
Objective Duranta repens is reported to contain a wide array of secondary metabolites,
including α-amylase and α-glucosidase inhibitors, and-has potent antioxidant activity. The …

[PDF][PDF] GCMS profile of bioactive secondary metabolites with therapeutic potential in the ethanolic leaf extracts of Azadirachta indica: A sacred traditional medicinal …

T Loganathan, A Barathinivas… - Journal of Drug …, 2021 - pdfs.semanticscholar.org
Neem (Azadirachta indica) a member of Meliaceae plays an immense role in human health
and disease which is attributed to its composition of Bioactive Secondary Metabolites …

Deciphering the key pathway for triterpenoid biosynthesis in Azadirachta indica A. Juss.: a comprehensive review of omics studies in nature's pharmacy

N Dave, A Iqbal, M Patel, T Kant, VK Yadav… - Frontiers in Plant …, 2023 - frontiersin.org
Since ancient times, Azadirachta indica, or Neem, has been a well-known species of plant
that produces a broad range of bioactive terpenoid chemicals that are involved in a variety of …

[HTML][HTML] Plasmodium falciparum Knockout for the GPCR-Like PfSR25 Receptor Displays Greater Susceptibility to 1,2,3-Triazole Compounds That Block Malaria …

BM Santos, DTG Gonzaga, FC da Silva, VF Ferreira… - Biomolecules, 2020 - mdpi.com
The search for new compounds with antimalarial activity is urgent, as resistance to ones in
the classical drug, has already been described in more than one continent. Compounds …