Accumulating evidence demonstrates that metabolic changes in the brain associated with
neuroinflammation, oxidative stress, and mitochondrial dysfunction play an important role in …

The energy demands of the brain are high: they account for at least 20% of the body's
energy consumption. Evolutionary studies indicate that the emergence of higher cognitive …

Abstract Magnetization Transfer Contrast (MTC) and Chemical Exchange Saturation
Transfer (CEST) experiments measure the transfer of magnetization from molecular protons …

The study of transient chemical phenomena by conventional NMR has proved elusive,
particularly for non-1H nuclei. For 13C, hyperpolarization using the dynamic nuclear …

Obesity, type 2 diabetes, and their associated comorbidities impact brain metabolism and
function and constitute risk factors for cognitive impairment. Alterations to taurine …

Functional magnetic resonance spectroscopy (fMRS) can be used to investigate
neurometabolic responses to external stimuli in-vivo, but findings are inconsistent. We …

Metabolic syndrome and diabetes impact brain function and metabolism. While it is well
established that rodents exposed to diets rich in saturated fat develop brain dysfunction …

Axonal degeneration is a critical, early event in many acute and chronic neurological
disorders. It has been consistently observed after traumatic brain injury, but whether axon …

Proton magnetic resonance spectroscopy (1H MRS) is a well-established technique for
quantifying the brain regional biochemistry in vivo. In most studies, however, the 1H MRS is …

Type 2 diabetes (T2D) is a metabolic disease with impact on brain function through
mechanisms that include glucose toxicity, vascular damage and blood–brain barrier (BBB) …