Defects in lysosomal function have been associated with numerous monogenic human
diseases typically classified as lysosomal storage diseases. However, there is increasing …

We assessed gene expression in tissue macrophages from various mouse organs. The
diversity in gene expression among different populations of macrophages was considerable …

Gross cytogenetic anomalies are traditionally being used as diagnostic, prognostic and
therapeutic markers in the clinical management of cancer, including childhood acute …

Although there is a binding site on the proteasome for the polyubiquitin chains attached to
degradation substrates by the ubiquitination machinery, it is currently unclear whether in …

c-Myc is one of the most potent regulators of cell cycle progression in higher eukaryotes.
Down-regulation of c-Myc is a critical event for growth inhibition induced by transforming …

Breast cancer is the second-most common cancer and second-leading cause of cancer
mortality in American women. The dysregulation of microRNAs (miRNAs) plays a key role in …

Transcription factor GATA-1 is essential for erythroid and megakaryocytic maturation. GATA-
1 mutations are associated with hematopoietic precursor proliferation and leukemogenesis …

Hepatic ischemia/reperfusion (I/R) is a major challenge for liver surgery and specific severe
conditions of chronic liver disease. Current surgical and pharmacological strategies are …

Salivary glands of blood-sucking arthropods contain a variety of compounds that prevent
platelet and clotting functions and modify inflammatory and immunological reactions in the …

The cellular repressor of E1A-stimulated genes (CREG) is a 220 amino acid glycoprotein
structurally similar to oxidoreductases. However, CREG does not have enzymatic activities …