Long non-coding RNAs: definitions, functions, challenges and recommendations

JS Mattick, PP Amaral, P Carninci… - … reviews Molecular cell …, 2023 - nature.com
Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …

Advances and trends in omics technology development

X Dai, L Shen - Frontiers in Medicine, 2022 - frontiersin.org
The human history has witnessed the rapid development of technologies such as high-
throughput sequencing and mass spectrometry that led to the concept of “omics” and …

NCBI GEO: archive for gene expression and epigenomics data sets: 23-year update

E Clough, T Barrett, SE Wilhite, P Ledoux… - Nucleic acids …, 2024 - academic.oup.com
Abstract The Gene Expression Omnibus (GEO) is an international public repository that
archives gene expression and epigenomics data sets generated by next-generation …

Gene regulation by long non-coding RNAs and its biological functions

L Statello, CJ Guo, LL Chen, M Huarte - Nature reviews Molecular cell …, 2021 - nature.com
Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs)
are widely expressed and have key roles in gene regulation. Recent studies have begun to …

Deciphering molecular interactions by proximity labeling

W Qin, KF Cho, PE Cavanagh, AY Ting - Nature methods, 2021 - nature.com
Many biological processes are executed and regulated through the molecular interactions of
proteins and nucleic acids. Proximity labeling (PL) is a technology for tagging the …

The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity

J Liu, M Gao, J He, K Wu, S Lin, L **, Y Chen, H Liu… - Nature, 2021 - nature.com
The RNA modification N 6-methyladenosine (m6A) has critical roles in many biological
processes,. However, the function of m6A in the early phase of mammalian development …

Cellular functions of long noncoding RNAs

RW Yao, Y Wang, LL Chen - Nature cell biology, 2019 - nature.com
A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential,
are transcribed from the mammalian genome. They are emerging as important regulators in …

Functional classification and experimental dissection of long noncoding RNAs

F Kopp, JT Mendell - Cell, 2018 - cell.com
Over the last decade, it has been increasingly demonstrated that the genomes of many
species are pervasively transcribed, resulting in the production of numerous long noncoding …

METTL3 regulates heterochromatin in mouse embryonic stem cells

W Xu, J Li, C He, J Wen, H Ma, B Rong, J Diao, L Wang… - Nature, 2021 - nature.com
Abstract METTL3 (methyltransferase-like 3) mediates the N 6-methyladenosine (m6A)
methylation of mRNA, which affects the stability of mRNA and its translation into protein …

The functions and unique features of long intergenic non-coding RNA

JD Ransohoff, Y Wei, PA Khavari - Nature reviews Molecular cell …, 2018 - nature.com
Long intergenic non-coding RNA (lincRNA) genes have diverse features that distinguish
them from mRNA-encoding genes and exercise functions such as remodelling chromatin …