Pancreatic stellate cells (PSCs) were identified in the early 1980s, but received much
attention after 1998 when the methods to isolate and culture them from murine and human …

Pancreatic stellate cells, normally quiescent, are capable of remarkable transition into their
activated myofibroblast-like phenotype. It is now commonly accepted that these cells play a …

Pancreatic stellate cell (PSC) is a type of pluripotent cell located between pancreatic lobules
and the surrounding area of acinars. When activated, PSC can be transformed into …

Improved understanding of the role of PSCs in pancreatic pathophysiology has prompted a
focus on translational studies aimed at develo** novel approaches to modulate PSC …

Understanding the organisation and role of the extracellular matrix (ECM) in islets of
Langerhans is critical for maintaining pancreatic β‐cells, and to recognise and revert the …

Objectives To investigate whether the activation of pancreatic stellate cells (PSCs) leads to
pancreatic β-cell dysfunction in type 2 diabetes mellitus (T2DM). Methods The pancreases of …

Disorders such as pancreatic or hepatic fibrosis are a cruel reminder that disruption of the
delicate physiological balance could result in severe pathological consequences. Fibrosis is …

Pluripotent pancreatic stellate cells (PSCs) receive growing interest in past decades. Two
types of PSCs are recognized–vitamin A accumulating quiescent PSCs and activated PSCs …

Microencapsulated islet transplantation was widely studied as a promising treatment for type
1 diabetes mellitus. However, micro-encapsulated islet transplantation has the following …

Simple Summary Pancreatic Ductal Adenocarcinoma (PDAC) is a rapidly fatal disease.
Diabetes mellitus is a major association of PDAC and is both a cause as well as a …