Signaling pathways that mediate cell-cell communication are essential for collective cell
behaviors in multicellular systems. The hedgehog (HH) pathway, first discovered and …

Cell-cell communication through evolutionarily conserved signaling pathways governs
embryonic development and adult tissue homeostasis. Deregulation of these signaling …

While cilia are recognized as important signaling organelles, the extent of ciliary functions
remains unknown because of difficulties in cataloguing proteins from mammalian primary …

Cholesterol is necessary for the function of many G-protein coupled receptors (GPCRs). We
find that cholesterol is not just necessary but also sufficient to activate signaling by the …

The Hedgehog (Hh) signaling pathway governs complex developmental processes,
including proliferation and patterning within diverse tissues. These activities rely on a tightly …

Primary cilia organize Hedgehog signaling and shape embryonic development, and their
dysregulation is the unifying cause of ciliopathies. We conducted a functional genomic …

To uncover regulatory mechanisms in Hedgehog (Hh) signaling, we conducted genome-
wide screens to identify positive and negative pathway components and validated top hits …

Purpose Ciliopathies are highly heterogeneous clinical disorders of the primary cilium. We
aim to characterize a large cohort of ciliopathies phenotypically and molecularly. Methods …

Polydactyly, also known as hyperdactyly or hexadactyly is the most common hereditary limb
anomaly characterized by extra fingers or toes, with various associated morphologic …

Primary cilia are immotile appendages that have evolved to receive and interpret a variety of
different extracellular cues. Cilia play crucial roles in intercellular communication during …