Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations
Mutations, the fuel of evolution, are first manifested as rare DNA changes within a population
of cells. Although next-generation sequencing (NGS) technologies have revolutionized the …
of cells. Although next-generation sequencing (NGS) technologies have revolutionized the …
Technological advances in cancer immunity: from immunogenomics to single-cell analysis and artificial intelligence
Y Xu, GH Su, D Ma, Y **ao, ZM Shao… - Signal Transduction and …, 2021 - nature.com
Immunotherapies play critical roles in cancer treatment. However, given that only a few
patients respond to immune checkpoint blockades and other immunotherapeutic strategies …
patients respond to immune checkpoint blockades and other immunotherapeutic strategies …
Detection of a SARS-CoV-2 variant of concern in South Africa
Continued uncontrolled transmission of SARS-CoV-2 in many parts of the world is creating
conditions for substantial evolutionary changes to the virus,. Here we describe a newly …
conditions for substantial evolutionary changes to the virus,. Here we describe a newly …
Broad betacoronavirus neutralization by a stem helix–specific human antibody
The spillovers of betacoronaviruses in humans and the emergence of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) variants highlight the need for broad …
respiratory syndrome coronavirus 2 (SARS-CoV-2) variants highlight the need for broad …
Ensembl 2021
Abstract The Ensembl project (https://www. ensembl. org) annotates genomes and
disseminates genomic data for vertebrate species. We create detailed and comprehensive …
disseminates genomic data for vertebrate species. We create detailed and comprehensive …
Detection of early seeding of Richter transformation in chronic lymphocytic leukemia
F Nadeu, R Royo, R Massoni-Badosa… - Nature medicine, 2022 - nature.com
Richter transformation (RT) is a paradigmatic evolution of chronic lymphocytic leukemia
(CLL) into a very aggressive large B cell lymphoma conferring a dismal prognosis. The …
(CLL) into a very aggressive large B cell lymphoma conferring a dismal prognosis. The …
Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity
The causative agent of coronavirus disease 2019 (COVID-19) is the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). For many viruses, tissue tropism is determined by …
syndrome coronavirus 2 (SARS-CoV-2). For many viruses, tissue tropism is determined by …
Clinically relevant mutations in core metabolic genes confer antibiotic resistance
Although metabolism plays an active role in antibiotic lethality, antibiotic resistance is
generally associated with drug target modification, enzymatic inactivation, and/or transport …
generally associated with drug target modification, enzymatic inactivation, and/or transport …
Alpha to Omicron: disease severity and clinical outcomes of major SARS-CoV-2 variants
FP Esper, TM Adhikari, ZJ Tu, YW Cheng… - The Journal of …, 2023 - academic.oup.com
Background Four severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
predominated in the United States since 2021. Understanding disease severity related to …
predominated in the United States since 2021. Understanding disease severity related to …
Deep learning-based prediction of the T cell receptor–antigen binding specificity
Neoantigens play a key role in the recognition of tumour cells by T cells; however, only a
small proportion of neoantigens truly elicit T-cell responses, and few clues exist as to which …
small proportion of neoantigens truly elicit T-cell responses, and few clues exist as to which …