Sleep and the price of plasticity: from synaptic and cellular homeostasis to memory consolidation and integration

G Tononi, C Cirelli - Neuron, 2014 - cell.com
Sleep is universal, tightly regulated, and its loss impairs cognition. But why does the brain
need to disconnect from the environment for hours every day? The synaptic homeostasis …

Molecular mechanisms of early and late LTP

SB Baltaci, R Mogulkoc, AK Baltaci - Neurochemical research, 2019 - Springer
LTP is the most intensively studied cellular model of the memory and generally divided at
least two distinct phases as early and late. E-LTP requires activation of CaMKII that initiates …

Map** the epigenomic and transcriptomic interplay during memory formation and recall in the hippocampal engram ensemble

A Marco, HS Meharena, V Dileep, RM Raju… - Nature …, 2020 - nature.com
The epigenome and three-dimensional (3D) genomic architecture are emerging as key
factors in the dynamic regulation of different transcriptional programs required for neuronal …

Genetic risk for schizophrenia: convergence on synaptic pathways involved in plasticity

J Hall, S Trent, KL Thomas, MC O'Donovan… - Biological psychiatry, 2015 - Elsevier
Recent large-scale genomic studies have revealed two broad classes of risk alleles for
schizophrenia: a polygenic component of risk mediated through multiple common risk …

[HTML][HTML] Arc protein: a flexible hub for synaptic plasticity and cognition

O Nikolaienko, S Patil, MS Eriksen… - Seminars in cell & …, 2018 - Elsevier
Mammalian excitatory synapses express diverse types of synaptic plasticity. A major
challenge in neuroscience is to understand how a neuron utilizes different types of plasticity …

[HTML][HTML] High-throughput, high-resolution map** of protein localization in mammalian brain by in vivo genome editing

T Mikuni, J Nishiyama, Y Sun, N Kamasawa, R Yasuda - Cell, 2016 - cell.com
A scalable and high-throughput method to identify precise subcellular localization of
endogenous proteins is essential for integrative understanding of a cell at the molecular …

PML: Regulation and multifaceted function beyond tumor suppression

KS Hsu, HY Kao - Cell & bioscience, 2018 - Springer
Promyelocytic leukemia protein (PML) was originally identified as a fusion partner of retinoic
acid receptor alpha in acute promyelocytic leukemia patients with the (15; 17) chromosomal …

Arc/Arg3. 1 function in long‐term synaptic plasticity: Emerging mechanisms and unresolved issues

H Zhang, CR Bramham - European Journal of Neuroscience, 2021 - Wiley Online Library
Arc (activity‐regulated cytoskeleton‐associated protein) is posited as a critical regulator of
long‐term synaptic plasticity at excitatory synapses, including long‐term potentiation, long …

Object recognition memory: distinct yet complementary roles of the mouse CA1 and perirhinal cortex

DA Cinalli Jr, SJ Cohen, K Guthrie… - Frontiers in molecular …, 2020 - frontiersin.org
While the essential contribution of the hippocampus to spatial memory is well established,
object recognition memory has been traditionally attributed to the perirhinal cortex (PRh) …

Role of palmitoylation of postsynaptic proteins in promoting synaptic plasticity

L Matt, K Kim, D Chowdhury, JW Hell - Frontiers in molecular …, 2019 - frontiersin.org
Many postsynaptic proteins undergo palmitoylation, the reversible attachment of the fatty
acid palmitate to cysteine residues, which influences trafficking, localization, and protein …