The key role of epigenetics in human disease prevention and mitigation
AP Feinberg - New England Journal of Medicine, 2018 - Mass Medical Soc
Epigenetics in Disease Prevention and Mitigation Epigenetics is the regulation of gene
expression through alterations in DNA or associated factors (other than the DNA sequence) …
expression through alterations in DNA or associated factors (other than the DNA sequence) …
[HTML][HTML] Childhood maltreatment and DNA methylation: A systematic review
DNA methylation (DNAm)–an epigenetic process that regulates gene expression–may
represent a mechanism for the biological embedding of early traumatic experiences …
represent a mechanism for the biological embedding of early traumatic experiences …
To predict, prevent, and manage post-traumatic stress disorder (PTSD): a review of pathophysiology, treatment, and biomarkers
Post-traumatic stress disorder (PTSD) can become a chronic and severely disabling
condition resulting in a reduced quality of life and increased economic burden. The disorder …
condition resulting in a reduced quality of life and increased economic burden. The disorder …
Successful treatment of post-traumatic stress disorder reverses DNA methylation marks
Epigenetic mechanisms play a role in the detrimental effects of traumatic stress and the
development of post-traumatic stress disorder (PTSD). However, it is unknown whether …
development of post-traumatic stress disorder (PTSD). However, it is unknown whether …
Recent genetics and epigenetics approaches to PTSD
Abstract Purpose of Review Following a life-threatening traumatic exposure, about 10% of
those exposed are at considerable risk for develo** posttraumatic stress disorder (PTSD) …
those exposed are at considerable risk for develo** posttraumatic stress disorder (PTSD) …
The effects of trauma, with or without PTSD, on the transgenerational DNA methylation alterations in human offsprings
Exposure to psychological trauma is a strong risk factor for several debilitating disorders
including post-traumatic stress disorder (PTSD) and depression. Besides the impact on …
including post-traumatic stress disorder (PTSD) and depression. Besides the impact on …
A review of epigenetic contributions to post-traumatic stress disorder
H Howie, CM Rijal, KJ Ressler - Dialogues in clinical neuroscience, 2019 - Taylor & Francis
Post-traumatic stress disorder (PTSD) is a syndrome which serves as a classic example of
psychiatric disorders that result from the intersection of nature and nurture, or gene and …
psychiatric disorders that result from the intersection of nature and nurture, or gene and …
Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR
Epigenetic differences may help to distinguish between PTSD cases and trauma-exposed
controls. Here, we describe the results of the largest DNA methylation meta-analysis of …
controls. Here, we describe the results of the largest DNA methylation meta-analysis of …
Epigenome-wide meta-analysis of PTSD symptom severity in three military cohorts implicates DNA methylation changes in genes involved in immune system and …
Epigenetic factors modify the effects of environmental factors on biological outcomes.
Identification of epigenetic changes that associate with PTSD is therefore a crucial step in …
Identification of epigenetic changes that associate with PTSD is therefore a crucial step in …
DNA methylation and expression profiles of whole blood in Parkinson's disease
AR Henderson, Q Wang, B Meechoovet… - Frontiers in …, 2021 - frontiersin.org
Parkinson's disease (PD) is the second most common age-related neurodegenerative
disease. It is presently only accurately diagnosed at an advanced stage by a series of motor …
disease. It is presently only accurately diagnosed at an advanced stage by a series of motor …