Gossypol toxicity from cottonseed products

ICN Gadelha, NBS Fonseca, SCS Oloris… - The Scientific World …, 2014 - Wiley Online Library
Gossypol is a phenolic compound produced by pigment glands in cotton stems, leaves,
seeds, and flower buds (Gossypium spp.). Cottonseed meal is a by‐product of cotton that is …

[HTML][HTML] Physicochemical features, functional characteristics, and health benefits of cottonseed oil: a review

MA Zia, SH Shah, S Shoukat, Z Hussain… - Brazilian Journal of …, 2021 - SciELO Brasil
Vegetable oils have their specific physicochemical properties due to which they are playing
vital role in human nutritional diet for health benefits. Cottonseed oil is obtained from various …

(−)-Gossypol enhances response to radiation therapy and results in tumor regression of human prostate cancer

L Xu, D Yang, S Wang, W Tang, M Liu, M Davis… - Molecular cancer …, 2005 - AACR
Radioresistance markedly impairs the efficacy of tumor radiotherapy and involves
antiapoptotic signal transduction pathways that prevent radiation-induced cell death. The …

Synthesis of gossypol atropisomers and derivatives and evaluation of their anti-proliferative and anti-oxidant activity

K Dodou, RJ Anderson, WJ Lough, DAP Small… - Bioorganic & medicinal …, 2005 - Elsevier
Gossypol 1, gossypolone 2, and a series of bis 3 and half Schiff's bases 4 of gossypol were
synthesised and tested for anti-proliferative and anti-oxidant activity.(−)-Gossypol (−)-1 was …

The immunosuppressive effect of gossypol in mice is mediated by inhibition of lymphocyte proliferation and by induction of cell apoptosis

W Xu, L Xu, H Lu, D Ou-Yang, H Shi, J Di… - Acta Pharmacologica …, 2009 - nature.com
Aim: To investigate the immunosuppressive effect of gossypol in mice both in vitro and in
vivo. Methods: The in vitro effect of gossypol on the proliferation of lymphocytes isolated from …

Moringa oleifera leaf flavonoids protect bovine mammary epithelial cells from hydrogen peroxide‐induced oxidative stress in vitro

J Liu, G Ma, Y Wang, Y Zhang - Reproduction in Domestic …, 2020 - Wiley Online Library
Bovine mammary epithelial cells (BMECs) of high‐producing dairy cows are subject to
constant oxidative stress as a result of high metabolic rate and physiological adaptation to …

[PDF][PDF] Extruded-expelled cottonseed meal decreases lymphocyte counts in male sheep

AP Braga, MV Maciel, DGF Guerra, I Maia… - Revue de Medecine …, 2012 - researchgate.net
Because of the toxicity of gossypol found in cottonseed, the present work aims to evaluate
the effects of extruded-expelled cottonseed meal on haematological and serum biochemical …

Direct electrochemiluminescence of CdTe quantum dots based on room temperature ionic liquid film and high sensitivity sensing of gossypol

L Hua, J Zhou, H Han - Electrochimica acta, 2010 - Elsevier
A new method with high sensitivity was developed to determine gossypol content using
CdTe quantum dot (QD) electrochemiluminescence (ECL) with a room temperature ionic …

[PDF][PDF] Gossypol acetic acid induces apoptosis in RAW264. 7 cells via a caspase-dependent mitochondrial signaling pathway

S Deng, H Yuan, J Yi, Y Lu, Q Wei… - Journal of …, 2013 - synapse.koreamed.org
To investigate the effects of gossypol acetic acid (GA) on proliferation and apoptosis of the
macrophage cell line RAW264. 7 and further understand the possible underlying …

Protective effect of ginkgo biloba against gossypol-induced apoptosis in human lymphocytes

U Ergun, E Yurtcu, MA Ergun - Cell biology international, 2005 - Elsevier
Ginkgo biloba (EGb 761) is a well-defined plant extract that directly scavenges hydroxyl
radicals. It is a potent antioxidant that inhibits apoptosis in cultured cells and is effective in …