Metallic nanosystems in the development of antimicrobial strategies with high antimicrobial activity and high biocompatibility

K Skłodowski, SJ Chmielewska-Deptuła… - International journal of …, 2023 - mdpi.com
Antimicrobial resistance is a major and growing global problem and new approaches to
combat infections caused by antibiotic resistant bacterial strains are needed. In recent years …

[HTML][HTML] Ceragenins and Ceragenin-Based Core-Shell Nanosystems as New Antibacterial Agents against Gram-Negative Rods Causing Nosocomial Infections

M Karasiński, U Wnorowska, B Durnaś, G Król… - Pathogens, 2023 - mdpi.com
The growing number of infections caused by multidrug-resistant bacterial strains, limited
treatment options, multi-species infections, high toxicity of the antibiotics used, and an …

[HTML][HTML] Bactericidal activity of ceragenin in combination with ceftazidime, levofloxacin, co-trimoxazole, and colistin against the opportunistic pathogen …

P Paprocka, A Mańkowska, K Skłodowski, G Król… - Pathogens, 2022 - mdpi.com
Background: Stenotrophomonas maltophilia (S. maltophilia) is an emerging opportunistic
Gram-negative rod causing nosocomial infections predominantly in immunocompromised …

Ceragenin CSA-13 displays high antibacterial efficiency in a mouse model of urinary tract infection

U Wnorowska, E Piktel, P Deptuła, T Wollny, G Król… - Scientific Reports, 2022 - nature.com
Ceragenins (CSAs) are synthetic, lipid-based molecules that display activities of natural
antimicrobial peptides. Previous studies demonstrated their high in vitro activity against …

Searching for Conjugates as New Structures for Antifungal Therapies

I Muszalska-Kolos, PM Dwiecki - Journal of Medicinal Chemistry, 2024 - ACS Publications
The progressive increase in fungal infections and the decrease in the effectiveness of
current therapy explain research on new drugs. The synthesis of compounds with proven …

Investigating the Effectiveness of Ceragenins against Acinetobacter baumannii to Develop New Antimicrobial and Anti-Adhesive Strategies

M Karasiński, U Wnorowska, T Daniluk… - International Journal of …, 2024 - mdpi.com
A growing body of experimental data indicates that ceragenins (CSAs), which mimic the
physicochemical properties of the host's cationic antimicrobial peptide, hold promise for the …

[HTML][HTML] Natural Antimicrobial Peptides and Their Synthetic Analogues for Effective Oral Microflora Control and Oral Infection Treatment—The Role of Ceragenins in …

M Czarnowski, U Wnorowska, M Łuckiewicz… - Pharmaceuticals, 2024 - mdpi.com
Oral diseases, both acute and chronic, of infectious or non-infectious etiology, represent
some of the most serious medical problems in dentistry. Data from the literature increasingly …

[HTML][HTML] Effect of Adding Gold Nanoparticles on the Anti-Candidal Activity and Release Profile of Itraconazole from Hydrogels

R Balwierz, P Biernat, D Bursy, M Shanaida… - Applied Sciences, 2024 - mdpi.com
Featured Application The work presents information on the potential for the synthesis of
hydrogels comprising gold nanoparticles coated with itraconazole, together with an …