Variability in disease presentation, progression and treatment response has been a central
challenge in medicine. Although variability in host factors and genetics are important, it has …

The function of cells in their native habitat often cannot be reliably predicted from genomic
data or from physiology studies of isolates. Traditional experimental approaches to study the …

Activity-based protein profiling (ABPP) is a technique that uses highly selective active-site
targeted chemical probes to label and monitor the state of proteins. ABPP integrates the …

Over the past decade, the gut microbiota has received considerable attention for its
interactions with the host. Microbial β-glucuronidase generated by this community has …

Long Stokes shift dyes that minimize cross-talk between the excitation source and
fluorescent emission to improve the signal-to-background ratio are highly desired for …

Highlights•Glycosidases carry out many essential functions across all domains of
life.•Activity-based probes can interrogate complex biological samples for glycosidase …

Despite the recognition, nearly a century ago, that the human microbiome plays a clinically
relevant role in drug disposition, mechanistic insights, and translational applications are still …

Recent studies of the human microbiome have offered new insights into how the microbiome
can impact cancer development and treatment. Specifically, in pancreatic ductal …

Bacterial β-glucuronidase enzymes (BGUSs) are at the interface of host-microbial metabolic
symbiosis, playing an important role in health and disease as well as medication outcomes …

β-Glucuronidase (GLU) is a hallmark enzyme for many malignant tumors, but
bioluminescence (BL) probes that enable GLU imaging in vivo have not been reported …